Elucidation of disturbance of spermatogenesis by spermatogonial stem cell activity
| Project/Area Number |
24791660
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KAMISAWA Hideyuki 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00551277)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 精子幹細胞 / UTF1 / 男性不妊症 / 造精機能障害 / 停留精巣 |
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| Outline of Final Research Achievements |
We performed this study to elucidate the mechanism of congenital poor spermatogenesis.
By using male fertility model animals and patients, we evaluated the relationship between spermatogonial stem cell (SSC) activity and spermatogenesis. Our results indicated that the expression pattern of UTF1 (undifferentiated embryonic cell transcription factor 1) in the testes could be suitable for predicting the risk of future infertility. And we elucidated that SSC activity of cryptorchid testes, one of the most major factor of male infertility, was decreased, and various gene expressions (i.e. EEF1A1, KDM5A and so on) regulated spermatogenesis. Moreover overexpression of KDM5A would induce abnormal epigenomic change of spermatogenesis by gene induction (KDM5A) study.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] Expediency of early orchiopexy for spermatogonial stem cell activity and apoptosis in cryptorchid testes.2013
Author(s)
Kamisawa Hideyuki, Mizuno Kentaro, Imura Makoto, Moritoki Yoshinobu, Nishio Hidenori, Nakane Akihiro, Kato Toshiki, Maruyama Tetsuji, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2013
Place of Presentation
San Diego Convention Center( San Diego, USA)
Related Report
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