| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We performed this study to elucidate the mechanism of congenital poor spermatogenesis.
By using male fertility model animals and patients, we evaluated the relationship between spermatogonial stem cell (SSC) activity and spermatogenesis. Our results indicated that the expression pattern of UTF1 (undifferentiated embryonic cell transcription factor 1) in the testes could be suitable for predicting the risk of future infertility. And we elucidated that SSC activity of cryptorchid testes, one of the most major factor of male infertility, was decreased, and various gene expressions (i.e. EEF1A1, KDM5A and so on) regulated spermatogenesis. Moreover overexpression of KDM5A would induce abnormal epigenomic change of spermatogenesis by gene induction (KDM5A) study.
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