The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

• Project/Area Number: 24791671
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: TANAKA Nobuyuki 慶應義塾大学, 医学部, 講師(非常勤) (60445244)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 尿路上皮癌 / 血管新生 / レニンアンギオテンシン / レニン・アンギオテンシン / ARB

Research Abstract

Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.

Research Products

• [Journal Article] Metastatic behavior of upper tract urothelial carcinoma after radical nephroureterectomy: association with primary tumor location. (2014)
  • Author(s): Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Kobayashi H, Ide H, Miyazaki Y, Obata J, Hoshino K, Shirotake S, Akita H, Kosaka T, Miyajima A, Momma T, Nakagawa K, Hasegawa S, Nakajima Y, Jinzaki M, Oya M
  • Journal Title: Ann Surg Oncol Volume: 21(3) Issue: 3 Pages: 1038-45
  • DOI: 10.1245/s10434-013-3349-z
  • Peer Reviewed
• [Journal Article] The Predictive Value of C-reactive Protein for Prognosis in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy: A Multi-institutional Study. (2014)
  • Author(s): Tanaka N, Kikuchi E, Shirotake S, Kanao K, Matsumoto K, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Ito Y, Kosaka T, Kodaira K, Oyama M, Miyajima A, Momma T, Nakagawa K, Ueno M, Oya M
  • Journal Title: Eur Urol Volume: 65(1) Issue: 1 Pages: 227-34
  • DOI: 10.1016/j.eururo.2012.11.050
  • Peer Reviewed
• [Journal Article] Independent Predictors for Bladder Outcomes after Treatment of Intravesical Recurrence following Radical Nephroureterectomy in Patients with Primary Upper Tract Urothelial Carcinoma. (2014)
  • Author(s): Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Hagiwara M, Kosaka T, Oyama M, Miyajima A, Momma T, Nakagawa K, Jinzaki M, Hasegawa S, Nakajima Y, Oya M
  • Journal Title: Ann Surg Oncol Volume: 21(9) Issue: 9 Pages: 3151-8
  • DOI: 10.1245/s10434-014-3657-y
  • Peer Reviewed
• [Journal Article] The predictive value of positive urine cytology for outcomes following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma: a multi-institutional study. (2014)
  • Author(s): Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Kobayashi H, Miyazaki Y, Ide H, Obata J, Hoshino K, Hayakawa N, Kosaka T, Oyama M, Miyajima A, Momma T, Nakagawa K, Jinzaki M, Nakajima Y, Oya M
  • Journal Title: Urol Oncol Volume: 32(1) Issue: 1 Pages: 48.e19-48.e26
  • DOI: 10.1016/j.urolonc.2013.07.003
  • Peer Reviewed
• [Journal Article] C-reactive protein: A biomarker of survival in patients with localized upper tract urothelial carcinoma treated with radical nephroureterectomy (2013)
  • Author(s): Jun Obata, Eiji Kikuchi, Nobuyuki Tanaka, Kazuhiro Matsumoto, Nozomi Hayakawa, Hiroki Ide, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
  • Journal Title: Urologic Oncology: Seminars and Original Investigations Volume: 31 Issue: 8 Pages: 1725-1730
  • DOI: 10.1016/j.urolonc.2012.05.008
  • Peer Reviewed
• [Journal Article] Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of Japanese multi-institutions (2013)
  • Author(s): Nobuyuki Tanaka, Eiji Kikuchi, Kent Kanao, Kazuhiro Matsumoto, Hiroaki Kobayashi, Yasumasa Miyazaki, Hiroki Ide, Jun Obata, Katsura Hoshino, Suguru Shirotake, Nozomi Hayakawa, Takeo Kosaka, Akira Miyajima, Tetsuo Momma, Ken Nakagawa, Shintaro Hasegawa, Yosuke Nakajima, Mototsugu Oya
  • Journal Title: British Journal of Urology Volume: 112 Issue: 2 Pages: 741-747
  • DOI: 10.1111/bju.12133
  • Peer Reviewed
• [Journal Article] Prognostic value of renin-angiotensin system blockade in non-muscle-invasive bladder cancer (2012)
  • Author(s): Yuge K, Miyajima A, Tanaka N, Shirotake S, Kosaka T, Kikuchi E, Oya M
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 12 Pages: 3987-93
  • DOI: 10.1245/s10434-012-2568-z
  • Peer Reviewed
• [Journal Article] Prognostic significance of high nuclear grade in patients with pathologic T1a renal cell carcinoma. (2012)
  • Author(s): Suzuki K, Mizuno R, Mikami S, Tanaka N, Kanao K, Kikuchi E, Miyajima A, Nakagawa K, Oya M.
  • Journal Title: Jpn J Clin Oncol. Volume: 42(9) Issue: 9 Pages: 831-835
  • DOI: 10.1093/jjco/hys109
  • Peer Reviewed
• [Presentation] Characteristics and Outcome in Metastatic Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy : The Multi-Institutional Experience (2013)
  • Author(s): Tanaka N, Kikuchi E, Shirotake S, et al
  • Organizer: 2013年米国泌尿器科学会
  • Place of Presentation: アトランタ
  • Year and Date: 2013-05-05
• [Presentation] Predictive value of positive urine cytology for prognosis in patients with upper tract urothelial carcinoma following radical nephroureterectomy (2013)
  • Author(s): Tanaka N, Kikuchi E, Miyazaki Y, et al
  • Organizer: 2013年米国泌尿器科学会
  • Place of Presentation: アトランタ
  • Year and Date: 2013-05-05
• [Presentation] The Distinct Association Between Primary Tumor Location and the Patterns of Metastatic Spread Following Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma (2013)
  • Author(s): Tanaka N, Kikuchi E, Kanao K, et al
  • Organizer: 2013年米国泌尿器科学会
  • Place of Presentation: アトランタ
  • Year and Date: 2013-05-05
• [Presentation] 抗がん剤治療が誘導する微小環境の変化に着目した浸潤性膀胱癌へのAngiotensin II receptor blocker (ARB)の治療応用 (2013)
  • Author(s): 田中伸之, 宮嶋哲, 小坂威雄, 菊地栄次, 大家基嗣
  • Organizer: 第101会日本泌尿器科学会総会
  • Place of Presentation: 札幌芸術文化の館
  • Year and Date: 2013-04-25
• [Presentation] 抗がん剤治療が誘導する微小環境の変化に着目した浸潤性膀胱癌へのAngiotensin II receptor blocker (ARB)の治療応用 (2013)
  • Author(s): 田中伸之 宮嶋哲 小坂威雄 菊地栄次 大家基嗣
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌芸術文化の館
• [Remarks]
  • URL: http://www.keio-urology.jp
• [Remarks] 慶應義塾大学医学部泌尿器科学教室
  • URL: http://www.keio-urology.jp