Therapy for advanced prostate cancer using small ubiquitin-like modifier
Project/Area Number |
24791677
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Osaka Medical College |
Principal Investigator |
Teruo Inamoto 大阪医科大学, 医学部, 准教授 (20330087)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 腫瘍学 / 泌尿器腫瘍 / ストレス / 前立腺癌 / 去勢抵抗性 |
Outline of Final Research Achievements |
Among all functional proteins which relate cancer biology has been found. Although, protein itself has limited role in living cells, and post-translational modification means lot in protein function. Authors and others found that protein molecule does work in combination with other molecules. Ubiquitin and SUMO, polypeptides, are emerging in cancer biology, DNA repair, translation, signal transduction, through its protein modification. TGFβ signaling pathway molecules, which has a decent role in prostate cancer survival, and oncogenes like p53, cell cycle regulators like p21, p27kip1 are all ubiquitinated, thereafter gain/loss function occurs. Expression of smad7, which is a target of ubiquitin-proteasome system differs depending on the malignancy. SUMO utilizes the similar pathway to ubiquitin.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Feasibility of Photodynamic Diagnosis for Challenging TURBt Cases Including Muscle Invasive Bladder Cancer, BCG Failure or 2nd-TUR2015
Author(s)
Tomoaki Takai, Teruo Inamoto, Kazumasa Komura, Yuki Yoshikawa, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Junko Kouno, Koichiro Minami, Hirofumi Uehara, Kiyoshi Takahara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Haruhito Azuma
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Journal Title
Asian Pac J Cancer Prev.
Volume: 16
Pages: 2297-2301
Related Report
Peer Reviewed / Open Access
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[Journal Article] Could Transurethral Resection of the Prostate Using the TURis System Take Over Conventional Monopolar Transurethral Resection of the Prostate? A Randomized Controlled Trial and Midterm Results2014
Author(s)
Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Hirofumi Uehara, Kiyoshi Takahara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Toshikazu Watsuji, Haruhito Azuma
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Journal Title
Urology
Volume: 84
Issue: 2
Pages: 405-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Adipose-derived stromal cells inhibit prostate cancer cell proliferation inducing apoptosis.2014
Author(s)
Takahara K, Ii M, Inamoto T, Komura K, Ibuki N, Minami K, Uehara H, Hirano H, Nomi H, Kiyama S, Asahi M, Azuma H.
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Journal Title
Biochem Biophys Res Commun
Volume: 446
Issue: 4
Pages: 1102-7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Age at diagnosis on prostate cancer survival undergoing androgen deprivation therapy as primary treatment in daily practice: results from Japanese observational cohort.2014
Author(s)
Inamoto T, Azuma H, Hinotsu S, Tsukamoto T, Oya M, Ogawa O, Kitamura T, Kazuhiro S, Naito S, Namiki M, Nishimura K, Hirao Y, Usami M, Murai M, Akaza H; Japan Study Group of Prostate Cancer (J-CaP).
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Journal Title
J Cancer Res Clin Oncol.
Volume: 140
Issue: 7
Pages: 1197-204
DOI
Related Report
Peer Reviewed
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[Journal Article] Single session of high-intensity focused ultrasound for localized prostate cancer : treatment outcomes and potential effect as a primary therapy2013
Author(s)
Komura K, Inamoto T, Takai T, Uchimoto T, Saito K, Tanda N, Kono J, Minami K, Uehara H, Fujisue Y, Takahara K, Hirano H, Nomi H, Watsuji T, Kiyama S, Azuma H
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Journal Title
World J Urol
Volume: -
Issue: 5
Pages: 1339-1345
DOI
Related Report
Peer Reviewed
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[Presentation] The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinom2015
Author(s)
Teruo Inamoto, Shigeru Sakano, Tomoaki Takai, Kazumasa Komura, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Kazuhiro Nagao, Ryo Inoue, Kiyoshi Takahara, Hideyasu Matsuyama, Haruhito Azuma
Organizer
AUA2015 Annual Meeting
Place of Presentation
NewOrleansMorial ConventionCenter(NewOrleans USA)
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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[Presentation] Prospective randomized trial of alpha-blocker combined with imidafenacin in the treatment of nocturia in patients with benign prostatic hyperplasia and concomitant overactive bladder syndrome: results of GOOD-NIGHT Study2012
Author(s)
Teruo Inamoto,Akira Tsujimura,Norio Nonomura,Haruhito Azuma, Hironobu Akino,Naoki Oguchi,Yasuhide Kitagawa,Naoki Segawa,Satoshi Tamada, Nobutaka Shimizu,etal.
Organizer
AUA 2012 Annual Meeting
Place of Presentation
Georgia World Congress Center(アメリカ・アトランタ)
Related Report
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