| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Outline of Final Research Achievements |
Among all functional proteins which relate cancer biology has been found. Although, protein itself has limited role in living cells, and post-translational modification means lot in protein function. Authors and others found that protein molecule does work in combination with other molecules. Ubiquitin and SUMO, polypeptides, are emerging in cancer biology, DNA repair, translation, signal transduction, through its protein modification. TGFβ signaling pathway molecules, which has a decent role in prostate cancer survival, and oncogenes like p53, cell cycle regulators like p21, p27kip1 are all ubiquitinated, thereafter gain/loss function occurs. Expression of smad7, which is a target of ubiquitin-proteasome system differs depending on the malignancy. SUMO utilizes the similar pathway to ubiquitin.
|
