Adipocytokines and follicular development

• Project/Area Number: 24791681
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Yamagata University
• Principal Investigator: HARA Shuichiro 山形大学, 医学部, 非常勤講師 (10436230)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: アディポサイトカイン / 卵胞体外培養 / インスリン抵抗性改善薬 / 多嚢胞性卵巣症候群 / PPAR-γ作動薬

Research Abstract

Polycystic ovary syndrome (PCOS) is a common ovulatory disorder in young women. We examined to clarify the pathogenesis of PCOS by using an in vitro mouse preantral follicle culture system. TNF-alpha is an aipocytokine, which raise insulin resistance. TNF-alpha directly inhibited follicular development. On the other hand, insulin-sensitizing drugs restored the TNF-alpha-mediated inhibition of follicular development.

Research Products

• [Journal Article] Peroxisome proliferator-activated receptor-γ agonists prevent tumor necrosis factor-α-mediated inhibition of FSH-induced follicle development and estradiol production in a preantral follicle culture system (2014)
  • Author(s): Hara S, Takahashi T, Igarashi H, Amita M, Matsuo K, Hasegawa A, and Kurachi H
  • Journal Title: Journal of mammalian ova research Volume: 31(1)
  • Peer Reviewed
• [Journal Article] Pioglitazone counteracts the tumor necrosis factor-alpha inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system (2013)
  • Author(s): Hara S, Takahashi T, Amita M, Matsuo K, Igarashi H, and Kurachi H
  • Journal Title: Jurnal of ovarian research Volume: 6(1) Pages: 69-69
  • Peer Reviewed
• [Journal Article] Pioglitazone counteracts the tumor necrosis factor-α inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system (2013)
  • Author(s): Hara S, Takahashi T, Amita M, Matsuo K, Igarashi H, Kurachi H
  • Journal Title: Journal of ovarian research Volume: 6 Issue: 1 Pages: 69-77
  • DOI: 10.1186/1757-2215-6-69
  • Peer Reviewed
• [Presentation] Effects of pioglitazone on follicular development and steroidogenesis in in vitro mouse preantral follicle culture (2012)
  • Author(s): Shuichiro Hara
  • Organizer: 米国生殖医学会
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] ピオグリタゾンの卵胞発育促進作用の検討 (2012)
  • Author(s): 原周一郎
  • Organizer: 日本生殖医学会
  • Place of Presentation: 長崎ブリックホール（長崎）