Neutralizing antibodies against HPV and prognosis of CIN

• Project/Area Number: 24791682
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: OCHI HIroyuki 筑波大学, 医学医療系, 講師 (90574145)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ヒトパローマウイルス / 血清疫学 / 子宮頸癌 / 子宮頸部前癌病変 / ヒトパピローマウイルス / ヒトパピローマウイル

Outline of Final Research Achievements

The purpose of this study is to analyze the association of neutralizing antibody generated by human papillomavirus (HPV) infections with the progression and persistence of low-grade cervical abnormalities. We analyzed follow-up date of patients enrolled in a prospective non- intervention cohort study.Our findings suggested that neutralizing antibody assays for women with low-grade squamous intraepithelial lesions (LSIL) may be useful for predictor of disease persistence and progression.

Research Products

• [Journal Article] HPV genotyping for triage of women with abnormal cervical cancer screening results: a multicenter prospective study (2015)
  • Author(s): Yuko Nakamura, Koji Matsumoto, Toyomi Satoh, Ken Nishide, Akiko Nozue, Koji Shimabukuro, Seiichi Endo, Kimihiro Nagai, Akinori Oki, Hiroyuki Ochi, Yukio Morishita, Masayuki Noguchi, Hiroyuki Yoshikawa
  • Journal Title: International Journal of Clinical Oncology Volume: 印刷中 Issue: 5 Pages: 974-981
  • DOI: 10.1007/s10147-015-0789-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions? (2012)
  • Author(s): Ochi H, Matsumoto K, Kondo K, Oki A, Furuta R, Hirai Y, Yasugi T, Takatsuka N, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Kanda T, Yoshikawa H
  • Journal Title: J Med Virol Volume: 84(7) Issue: 7 Pages: 1128-1134
  • DOI: 10.1002/jmv.23258
  • Peer Reviewed
• [Presentation] HPV16/18/31/52/58型血清中和抗体と (2015)
  • Author(s): 越智寛幸, 沖明典, 八杉利治, 平井康夫, 八重樫伸生, 三橋暁, 藤井多久磨, 川名敬, 渡部洋, 横山正俊, 青木陽一, 古田玲子, 吉川裕之
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-10