Carcinogenesis of ovarian clear cell adenocarcinoma

• Project/Area Number: 24791683
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Chiba University
• Principal Investigator: NISHIKIMI Kyoko 千葉大学, 医学部附属病院, 助教 (00536302)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 婦人科腫瘍学 / 卵巣明細胞腺癌

Research Abstract

Ovarian clear cell adenocarcinoma (CCA) is frequently associated with endometriosis, and less often with adenofibroma. We investigated loss of BAF250a expression, which is encoded ARID1A, in adenofibroma-related CCA and compared with that in endometriosis-related CCA. Loss of BAF250a expression was significantly less frequent in adenofibroma alone CCA compared with endometriosis alone CCA.

Research Products

• [Journal Article] III, IV 期進行卵巣がんに対する治療戦略 進行卵巣がんに対する治療戦略 PDSと IDS (2013)
  • Author(s): 楯 真一, 錦見 恭子, 山本 憲子, 植原貴史, 碓井 宏和, 三橋 暁, 生水 真紀夫, 加藤 一喜
  • Journal Title: 日本婦人科腫瘍学会雑誌 Volume: 31巻 Pages: 114-119
• [Presentation] 上皮性卵巣癌 T2・T3a/b 期の手術療法 (2013)
  • Author(s): 錦見 恭子, 楯 真一, 加藤 一喜, 山本 憲子, 植原 貴史, 碓井 宏和, 三橋暁, 生水 真紀夫
  • Organizer: 第54回日本婦人科腫瘍学会
  • Place of Presentation: 東京
• [Presentation] 卵巣明細胞腺癌と内頸部型粘液性境界悪性腫瘍における嚢胞壁結節の所見 (2013)
  • Author(s): 林田弘美, 楯真一, 山本憲子, 錦見恭子, 碓井宏和, 三橋暁, 岩本雅美, 清川貴子, 生水真紀夫
  • Organizer: 第54回日本婦人科腫瘍学会
  • Place of Presentation: 東京
• [Presentation] BAF250a (ARID1A) Expression in Ovarian Clear Cell Adenocarcinoma with an Adenofibromatous Component (2013)
  • Author(s): Kyoko Nishikimi, Takako Kiyokawa, Masami Iwamoto, Shinichi Tate, Takashi Kisimoto, Kazunori Fugo, Makio Shozu
  • Organizer: United States & Canadian Academy of Pathology 102nd Annual Meeting
  • Place of Presentation: Baltimore, USA
• [Presentation] Adenofibromaを伴う卵巣明細胞腺癌におけるBAF250a(ARID1A)の発現 (2013)
  • Author(s): 錦見 恭子, 楯 真一, 清川 貴子, 岩本 雅美, 山本 憲子, 植原 貴史, 碓井 宏和, 三橋 暁, 生水 真紀夫
  • Organizer: 第65回日本産科婦人科学会
  • Place of Presentation: 札幌
• [Presentation] BAF250a (ARID1A) Expression in Ovarian Clear Cell Adenocarcinoma with an Adenofibromatous Component (2013)
  • Author(s): Kyoko Nishikimi
  • Organizer: United States and Canadian Academy of Pathology
  • Place of Presentation: Baltimore, USA
• [Presentation] Adenofibroma を伴う卵巣明細胞腺癌における BAF250a(ARID1A)の発現 (2012)
  • Author(s): 錦見 恭子, 楯 真一, 清川 貴子, 平敷好一郎, 海野 洋一, 伊澤 美彦, 田中尚武, 真田 道夫, 岩崎 秀昭, 山本 憲子, 松井 英雄, 松本 玲子, 佐久間 有加, 遠藤 信夫, 河原井 麗正, 神山 正明, 嘉藤 貴子, 河田 誠, 黒田 香織, 岡嶋 祐子, 生水 真紀夫
  • Organizer: 第64回日本産科婦人科学会
  • Place of Presentation: 神戸