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Effects of metformin in combination with chemotherapeutic agents on endometrial carcinoma cells

Research Project

Project/Area Number 24791686
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionChiba University

Principal Investigator

UEHARA Takashi  千葉大学, 医学(系)研究科(研究院), 助教 (70568659)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords婦人科腫瘍 / 子宮体癌 / メトホルミン / 抗がん薬 / 婦人科腫瘍学
Research Abstract

We assessed the anti-cancer effect of metformin in combination with chemotherapeutic agent (cisplatin) on endometrial cancer cell line. Metformin inhibited endometrial cancer cell proliferation, and potentiated the anti-cancer effect of cisplatin on endometrial cancer cell line. These effects were attenuated under hypoxic condition compared to normoxic condition, though were not antagonized.
Administration of metformin with cisplatin does not affect the efficacy of cisplatin, and metformin without cisplatin inhibits cancer cell proliferation. Administration of metformin in combination with cisplatin on the treatment of endometrial cancer probably enhances the therapeutic effects.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Incidence, Risk Factors and Treatment Outcomes of Extravasation of Cytotoxic Agents in an Outpatient Chemotherapy Clinic2014

    • Author(s)
      Sakaida Emiko, Sekine Ikuo, Iwasawa Shunichiro, Kurimoto Ryota, Uehara Takashi, Ooka Yoshihiko, Akanuma Naoki, Tada Yuji, Imai Chiaki, Oku Tomoko, Takiguchi Yuichi
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(2) Pages: 168-71

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of the history of breast cancer and of hormone therapy in uterine carcinosarcoma2012

    • Author(s)
      Uehara Takashi, Onda Takashi, Togami Shinichi, Amano Tsukuru, Tanikawa Michihiro, Sawada Morio, Ikeda Shun-ichi, Kato Tomoyasu, Kasamatsu Takahiro
    • Journal Title

      International Journal of Gynecological Cancer

      Volume: 22 Pages: 280-285

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numerous psammoma bodies in cervical cytology of high-grade endocervical adenocarcinoma

    • Author(s)
      Uehara Takashi, Kiyokawa Takako, Tate Uehara Takashi, Kiyokawa Takako, Tate
    • Journal Title

      Cytopathology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] メトホルミンは単独および抗がん薬との併用で子宮体癌細胞の増殖を抑制する2013

    • Author(s)
      植原貴史, 三橋暁, 鶴岡信栄, 石川博士, 碓井宏和, 生水真紀夫
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] メトホルミンは単独および抗がん薬との併用で子宮体癌細胞の増殖を抑制する2013

    • Author(s)
      植原貴史、三橋暁、鶴岡信栄、石川博士、碓井宏和、生水真紀夫
    • Organizer
      日本産科婦人科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Metformin Combination with Cytotoxic Chemotherapeutic Agents in Endometrial Cancer Cell Lines2012

    • Author(s)
      Takashi Uehara, Akira Mitsuhashi, Nobuhide Tsuruoka, Hiroshi Ishikawa, Hirokazu Usui, Makio Shozu
    • Organizer
      15 th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体癌細胞株に対するメトホルミンと抗がん薬の増殖抑制効果2012

    • Author(s)
      植原貴史, 三橋暁, 鶴岡信栄, 石川博士, 碓井宏和, 山澤功二, 生水真紀夫
    • Organizer
      第10回日本臨床腫瘍学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体癌細胞株に対するメトホルミンと抗がん薬の併用による細胞増殖抑制効果2012

    • Author(s)
      植原貴史、三橋暁、鶴岡信栄、石川博士、碓井宏和、山澤功二、生水真紀夫
    • Organizer
      日本臨床腫瘍学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Metformin Combination with Cytotoxic Chemotherapeutic Agents in Endometrial Cancer Cell Line2012

    • Author(s)
      Uehara Takashi, Mitsuhashi Akira, Tsuruoka Nobuhide, Isikawa Hiroshi, Usui Hirokazu, Yamazawa Koji, Shozu Makio
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Book] 「悪性腫瘍の病態生理, 症状, 治療について概説できる」, スタンダード薬学シリーズ 6, 日本薬学会編, 薬と疾病, III. 薬物治療(2)および薬物治療に役立つ情報, 第2版2012

    • Author(s)
      植原貴史
    • Publisher
      東京化学同人, 東京
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/gyne/staff/staff_t_uehara.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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