the bradykinin system in endometriosis

• Project/Area Number: 24791687
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama (2013); The University of Tokyo (2012)
• Principal Investigator: YOSHINO Osamu 富山大学, 大学院医学薬学(医学), 准教授 (00466757)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 子宮内膜症 / ブラジキニン / 疼痛

Research Abstract

In the treatment for endometriosis, a new technique which contains therapy for both endometriosis and infertility is required. In the preset study, we found bradykinin system is involved in endometriosis. Also, we found that the suppression of bradykinin receptor might be a new therapy for endometriosis.

Research Products

• [Journal Article] The Role of Bone Morphogenetic Protein 6 in Accumulation and Regulation of Neutrophils in the Human Ovary. (2014)
  • Author(s): Akiyama I, Yoshino O et al.
  • Journal Title: Reprod Sci. Volume: in press
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. (2014)
  • Author(s): Akiyama I, Yoshino O et al.
  • Journal Title: Reprod Sci. Volume: 21(4) Issue: 4 Pages: 477-82
  • DOI: 10.1177/1933719113503411
  • Peer Reviewed
• [Journal Article] The significance of serum anti-Müllerian hormone (AMH) levels in patients over age 40 in first IVF treatment (2013)
  • Author(s): Tokura Y, Yoshino O, Ogura-Nose S, Motoyama H, Harada M, Osuga Y, Shimizu Y, Ohara M, Yorimitsu T, Nishii O, Kozuma S, Kawamura T
  • Journal Title: J Assist Reprod Genet Volume: 30(6) Pages: 821-5
  • Peer Reviewed
• [Journal Article] Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells (2013)
  • Author(s): Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S
  • Journal Title: J Clin Endocrinol Metab Volume: 98(4) Pages: 1583-90
  • Peer Reviewed
• [Journal Article] Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinases-1 (MMP-1) from human decidual cells, and the production was reduced by progesterone (2013)
  • Author(s): Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Inoue S, Fujii T, Kozuma S
  • Journal Title: Am J Reprod Immunol Volume: 69(5) Pages: 454-62
  • Peer Reviewed
• [Journal Article] Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells (2013)
  • Author(s): Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Fujii T, Kozuma S
  • Journal Title: Am J Reprod Immunol Volume: 69(3) Pages: 240-7
  • Peer Reviewed
• [Journal Article] Follistatin is induced by IL-1β and TNF-α in stromal cells from endometrioma (2013)
  • Author(s): Akiyama I, Yoshino O, Osuga Y, Izumi G, Urata Y, Hirota Y, Hirata T, Harada M, Koga K, Ogawa K, Kozuma S
  • Journal Title: Reprod Sci Volume: 20(6) Pages: 675-9
  • Peer Reviewed
• [Journal Article] 子宮内膜症におけるブラジキニンに関する検討 (2013)
  • Author(s): 吉野 修
  • Journal Title: 産科と婦人科 Volume: vol. 80 No 11 Pages: 1509-1510
• [Journal Article] 子宮内膜症におけるブラジキニンに関する検討 (2013)
  • Author(s): 吉野 修
  • Journal Title: 産科と婦人科 Volume: Vol.80 No.11 Pages: 1509-1510
• [Journal Article] Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells (2013)
  • Author(s): Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S
  • Journal Title: J Clin Endocrinol Metab Volume: 98(4) Issue: 4 Pages: 1583-90
  • DOI: 10.1210/jc.2012-3475
  • Peer Reviewed
• [Journal Article] Cyclic Stretch Augments Production of Neutrophil Chemokines and Matrix Metalloproteinases-1 (MMP-1) from Human Decidual Cells, and the Production was Reduced by Progesterone. (2013)
  • Author(s): Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Inoue S, Fujii T, Kozuma S
  • Journal Title: Am J Reprod Immunol Volume: 69 Issue: 5 Pages: 454-462
  • DOI: 10.1111/aji.12092
  • Peer Reviewed
• [Journal Article] Follistatin is induced by IL-1βand TNF-αin stromal cells from endometrioma (2013)
  • Author(s): Akiyama I, Yoshino O, Osuga Y, Izumi G, Urata Y, Hirota Y, Hirata T, Harada M, Koga K, Ogawa K, Kozuma S
  • Journal Title: Reprod Sci Volume: 20(6) Issue: 6 Pages: 675-9
  • DOI: 10.1177/1933719112463253
  • Peer Reviewed
• [Journal Article] Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells. (2013)
  • Author(s): Zhao Y1, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Fujii T, Kozuma S.
  • Journal Title: Am J Reprod Immunol. Volume: 69 Issue: 3 Pages: 240-7
  • DOI: 10.1111/aji.12061
  • Peer Reviewed
• [Journal Article] The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary (2012)
  • Author(s): Akiyama I, Yoshino O, Osuga Y, Shi J, Hirota Y, Hirata T, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y
  • Journal Title: Am J Reprod Immunol Volume: 68(6) Pages: 491-8
  • Peer Reviewed
• [Journal Article] Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells (2012)
  • Author(s): Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, Hirata T, Hirota Y, Harada M, Hasegawa A, Taketani Y
  • Journal Title: Fertil Steril Volume: 98(5)
  • Peer Reviewed
• [Journal Article] Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells : possible involvement of TSLP in endometriosis (2012)
  • Author(s): Urata Y, Osuga Y, Izumi G, Takamura M, Koga K, Nagai M, Harada M, Hirata T, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Hum Reprod Volume: 27(10) Pages: 3028-35
  • Peer Reviewed
• [Journal Article] Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia (2012)
  • Author(s): Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Fertil Steril Volume: 98(4) Pages: 917-21
  • Peer Reviewed
• [Journal Article] Anti-Mullerian hormone (AMH) is induced by bone morphogenetic protein (BMP) cytokines in human granulosa cells (2012)
  • Author(s): Ogura-Nose S, Yoshino O, Osuga Y, Shi J, Hiroi H, Yano T, Taketani Y
  • Journal Title: Eur J Obstet Gynecol Reprod Biol Volume: 164(1) Pages: 44-7
  • Peer Reviewed
• [Journal Article] Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells (2012)
  • Author(s): Shi J, Yoshino O, Osuga Y, Akiyama I, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y.
  • Journal Title: Fertil Steril. Volume: 97 Issue: 4 Pages: 979-983
  • DOI: 10.1016/j.fertnstert.2012.01.100
  • Peer Reviewed
• [Journal Article] Anti-Mullerian hormone (AMH) is induced by bone morphogenetic protein (BMP) cytokines in human granulosa cells. (2012)
  • Author(s): Ogura-Nose S, Yoshino O, Osuga Y, Shi J, Hiroi H, Yano T, Taketani Y.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol. Volume: 164 Issue: 1 Pages: 44-7
  • DOI: 10.1016/j.ejogrb.2012.05.017
  • Peer Reviewed
• [Journal Article] Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia. (2012)
  • Author(s): Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Fertil Steril Volume: 98 Issue: 4 Pages: 917-21
  • DOI: 10.1016/j.fertnstert.2012.06.038
  • Peer Reviewed
• [Journal Article] Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis. (2012)
  • Author(s): Urata Y, Osuga Y, Izumi G, Takamura M, Koga K, Nagai M, Harada M, Hirata T, Hirota Y, Yoshino O, Taketani Y.
  • Journal Title: Hum Reprod. Volume: 27 Pages: 3028-35
  • Peer Reviewed
• [Journal Article] Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells (2012)
  • Author(s): Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, Hirata T, Hirota Y, Harada M, Hasegawa A, Taketani Y
  • Journal Title: Fertil Steril Volume: 98 Issue: 5 Pages: 1218-24
  • DOI: 10.1016/j.fertnstert.2012.07.1117
  • Peer Reviewed
• [Journal Article] The Localization and Regulation of Proprotein Convertase Subtilisin/Kexin (PCSK) 6 in Human Ovary. (2012)
  • Author(s): Akiyama I, Yoshino O, Osuga Y, Shi J, Hirota Y, Hirata T, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y.
  • Journal Title: Am J Reprod Immunol. Volume: 68 Issue: 6 Pages: 491-498
  • DOI: 10.1111/aji.12003
  • Peer Reviewed
• [Presentation] MRIを用いた子宮筋腫の新たな評価法 (2013)
  • Author(s): 吉野 修
  • Organizer: 第４回婦人科ホルモン依存性疾患研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 筋層内子宮筋腫により誘導される 子宮内膜の異常蠕動は妊娠率を低下させる。 (2013)
  • Author(s): 吉野 修、齋藤 滋、 西井 修、 折坂 誠
  • Organizer: 第４１回 北陸産婦人科学会
  • Place of Presentation: 新潟
• [Presentation] "子宮筋腫核出術は子宮内膜のT2値を低下させる。 " (2013)
  • Author(s): 吉野 修 、 齋藤 滋 、西井 修
  • Organizer: 第61回 北日本産婦人科学会
  • Place of Presentation: 旭川
• [Presentation] 卵巣顆粒膜細胞におけるAMHの発現はbone morphogenetic protein (BMP)サイトカインにより制御される。 (2013)
  • Author(s): 吉野 修、能瀬 さやか ら
  • Organizer: 第28回日本生殖免疫学会総会
  • Place of Presentation: 神戸