Immulogogical system mediated by antimicropeptide at the uterine cervix

• Project/Area Number: 24791688
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: NAGAMATSU Takeshi 東京大学, 医学部附属病院, 講師 (60463858)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 抗菌ペプチド / 産婦人科学 / 早産 / 羊膜絨毛膜炎

Outline of Final Research Achievements

This study aimed to clarify the involvement of antimicropeptides, SLPI and elafin in normal pregnancy and preterm labor. SLPI expression level at the uterine cervix elevated gradually in the course of pregnancy and the SLPI concentration in cervical mucus especially increased within 7 days prior to delivery. In women with preterm labor, the expression level of elafin and SLPI was higher in women who ended in preterm birth than in women who extended pregnancy until term. These findings implied that those antimicropeptides are involved in the cervical remodeling process at delivery and immune protection during pregnancy.

Research Products

• [Journal Article] Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor (2015)
  • Author(s): Itaoka N, Nagamatsu T, Schust DJ, Ichikawa M, Sayama S, Iwasawa-Kawai Y, Kawana K, Yamashita T, Osuga Y, Fujii T.
  • Journal Title: American journal of reproductive immunology Volume: 未定 Issue: 6 Pages: 536-544
  • DOI: 10.1111/aji.12354
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 頸管粘液中のα1MG、SLPI濃度上昇は陣痛発来予測因子となり得る－正期産妊婦における検討－ (2015)
  • Author(s): 鮫島大輝、永松健、板岡奈央、佐山晴亮、小松篤史、川名敬、山下隆博、大須賀穣、藤井知行
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-10 – 2015-04-12
• [Presentation] 絨毛膜羊膜炎における抗菌ペプチドelafinの発現および発現誘導因子について (2014)
  • Author(s): 板岡奈央、永松健、市川麻祐子、佐山晴亮、河合有希、矢部慎一郎、川名敬、山下隆博、大須賀穣、藤井知行
  • Organizer: 第66回日本産科婦人科学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] 妊娠中の子宮頸管におけるelafinとSLPIの生理的発現および切迫早産症例での変化ついての検討 (2013)
  • Author(s): 板岡奈央、永松健、藤井知行、市川麻祐子、佐山晴亮、矢部慎一郎、川名敬、山下隆博、上妻志郎
  • Organizer: 第65回日本産科婦人科学会
  • Place of Presentation: 札幌
• [Presentation] Elafin and SLPI at the uterine cervix during human pregnancy as candidate molecular markers for preterm birth. (2013)
  • Author(s): Nao ITAOKA, Takeshi NAGAMATSU, Mayuko ICHIKAWA,
  • Organizer: The 14th International Symposium for Immunology of Reproduction
  • Place of Presentation: Boston, USA
• [Presentation] 羊膜絨毛膜炎におけるelafinとSLPIの発現および発現誘導因子について (2013)
  • Author(s): 板岡奈央、永松健、市川麻祐子、佐山晴亮、河合有希、矢部慎一郎、川名敬、山下隆博、藤井知行
  • Organizer: 第28回日本生殖免疫学会
  • Place of Presentation: 西宮
• [Presentation] Expression and biological functions of Elafin and SLPI at the uterine cervix in the fetal membrane during pregnancy (2012)
  • Author(s): Nao ITAOKA, Takeshi NAGAMATSU, Tomoyuki FUJII
  • Organizer: The 20th FIGO World Congress of Gynecologic and Obstetrics
  • Place of Presentation: Rome, Italy
• [Presentation] 切迫早産の予後予測における顆粒球エラスターゼ検査の意義 (2012)
  • Author(s): 森田一輝、永松健、堀越嗣博、兵藤博信、山下隆博、亀井良政、藤井知行、上妻志郎、武谷雄二
  • Organizer: 第64回日本産科婦人科学会
  • Place of Presentation: 神戸