Detection of micrometastasis of lymphnodes in sentinel node navigation surgery for uterine cervical cancer

• Project/Area Number: 24791693
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Niigata University
• Principal Investigator: NISHINO KOJI 新潟大学, 医歯学総合病院, 助教 (70447598)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮頸癌 / センチネルリンパ節 / 微小転移

Outline of Final Research Achievements

In the current study, we achieved success to detect sentinel nodes (SN) at pelvic external iliac and obturator lesion in sentinel node navigation surgery by blue dye method for uterine cervical cancer cases received radical hysterectomy. There were no cases with non-SN metastasis in which case with SN metastasis, reached 100% negative predictive value. We could detect node metastasis by RT-PCR method of all involved nodes diagnosed by conventional pathological procedure, but we had no cases with micrometastasis of lymphnodes which we tried to detect only by RT-PCR but conventional pathological diagnosis in our study, so further investigations are recommended.