| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated the effects of H2 on oxidative stress-based fetal brain damage. We used an intrauterine ischemia-reperfusion rat model, which fetal brain damage is induced by the transient occlusion of the bilateral utero-ovarian arteries. Neonatal growth retardation was alleviated and the degeneration of fetal hippocampal neuronal cells was ameliorated by maternal H2 administration. Lastly, 8-week-old rats were subjected to a behavioral test. Maternal H2 administration improved the reference memory of the offspring. The hydrogen concentration was increased in the placenta and fetus after H2 administration to the mother, and the markers of oxidative stress were decreased in placenta and fetal brain. These results suggest that H2 exerts an anti-oxidative effect on the feto-maternal unit.
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