Comprehensive analysis of local immune state of ovarian cancers may provide a tool for the application of immune therapies to treat ovarian cancer patients.
| Project/Area Number |
24791701
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HAMANISHI Junzo 京都大学, 医学(系)研究科(研究院), 助教 (80378736)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 婦人科腫瘍学 |
|---|
| Research Abstract |
Comprehensive analysis of local immune state of ovarian cancers by using hierarchical clustering of tumor-infiltrating immune cells and immunosuppressive factors was used to identify a subgroup of ovarian cancer patients with a better prognosis. This study also suggested that immunosuppressive factors might influence the pattern of tumor-infiltrating immune cells. The analyses shown here may lead to a precise understanding of the local immune status and provide a tool for the application of immune therapies to treat ovarian cancer patients.
|
Report
(3 results)
Research Products
(44 results)
-
-
-
-
-
-
[Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma2013
Author(s)
T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
-
Journal Title
Molecular carcinogenesis
Volume: Sep 17
Issue: 1
Pages: 1-15
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers.2013
Author(s)
Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
-
Journal Title
Int J Cancer.
Volume: 133
Issue: 9
Pages: 2234-44
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers.2013
Author(s)
Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
-
Journal Title
Int J Cancer
Volume: 133
Pages: 2234-44
Related Report
-
[Journal Article] PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction.2013
Author(s)
Abiko K, Mandai M, Hamanishi J, Yoshioka Y, Matsumura N, Baba T, Yamaguchi K, Murakami R, Yamamoto A, Kharma B, Kosaka K, Konishi I.
-
Journal Title
Clin Cancer Res.
Volume: 19
Issue: 6
Pages: 1363-1374
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
