Comprehensive analysis of local immune state of ovarian cancers may provide a tool for the application of immune therapies to treat ovarian cancer patients.

• Project/Area Number: 24791701
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: HAMANISHI Junzo 京都大学, 医学(系)研究科(研究院), 助教 (80378736)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 婦人科腫瘍学

Research Abstract

Comprehensive analysis of local immune state of ovarian cancers by using hierarchical clustering of tumor-infiltrating immune cells and immunosuppressive factors was used to identify a subgroup of ovarian cancer patients with a better prognosis. This study also suggested that immunosuppressive factors might influence the pattern of tumor-infiltrating immune cells. The analyses shown here may lead to a precise understanding of the local immune status and provide a tool for the application of immune therapies to treat ovarian cancer patients.

Research Products

• [Journal Article] Treatment decision-making for post-partum hemorrhage using dynamic contrast-enhanced computed tomography. (2014)
  • Author(s): Kawamura Y, Kondoh E, Hamanishi J, Kawasaki K, Fujita K, Ueda A, Kawamura A, Mogami H, Konishi I.
  • Journal Title: J Obstet Gynaecol Res. Volume: 40 Issue: 1 Pages: 67-74
  • DOI: 10.1111/jog.12123
  • Peer Reviewed
• [Journal Article] がん免疫療法の最前線再発・進行卵巣がんに対する抗 PD-1 抗体を用いた免疫療法 (2014)
  • Author(s): 濵西潤三 万代昌紀 安彦郁 松村謙臣 小西郁生
  • Journal Title: 産科と婦人科
• [Journal Article] Recurrence of a carcinoid tumor of the ovary 13 years after the primary surgery : A case report (2013)
  • Author(s): Amano Y, Mandai M, Baba T, Hamanishi J, Yoshioka Y, Matsumura N, Konishi I
  • Journal Title: Oncol Lett Volume: 6(5) Pages: 1241-1244
• [Journal Article] A novel diagnostic criterion for lymph node metastasis in cervical cancer using multi-detector computed tomography. (2013)
  • Author(s): Yamanoi K, Matsumura N, Kido A, Baba T, Hamanishi J, Yamaguchi K, Yoshioka Y, Abou Taleb H, Togashi K, Konishi I.
  • Journal Title: Gynecol Oncol. Volume: 131 Issue: 3 Pages: 707-7
  • DOI: 10.1016/j.ygyno.2013.10.014
  • NAID: 120005357243
  • Peer Reviewed
• [Journal Article] Transverse fundal uterine incision for delivery of extremely low birth-weight infants (2013)
  • Author(s): Taga A, Kondoh E, Hamanishi J, Kawasaki K, Fujita K, Mogami H, Konishi I
  • Journal Title: J Matern Fetal Neonatal Med
• [Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma (2013)
  • Author(s): T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
  • Journal Title: Molecular carcinogenesis Volume: Sep 17 Issue: 1 Pages: 1-15
  • DOI: 10.1002/mc.22072
  • Peer Reviewed
• [Journal Article] Ileal perforation and massive intestinal haemorrhage from endometriosis in pregnancy: case report and literature review. (2013)
  • Author(s): Nishikawa A, Kondoh E, Hamanishi J, Yamaguchi K, Ueda A, Sato Y, Konishi I.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol. Volume: 170 Issue: 1 Pages: 20-4
  • DOI: 10.1016/j.ejogrb.2013.04.018
  • NAID: 120005323881
  • Peer Reviewed
• [Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers. (2013)
  • Author(s): Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
  • Journal Title: Int J Cancer. Volume: 133 Issue: 9 Pages: 2234-44
  • DOI: 10.1002/ijc.28220
  • Peer Reviewed
• [Journal Article] 卵巣がんに対する抗 PD-1 抗体を用いた新規分子標的治療の医師主導治験 (2013)
  • Author(s): 濵西潤三 小西郁生
  • Journal Title: 京都がん研究会メールマガジン
• [Journal Article] Recurrence of a carcinoid tumor of the ovary 13 years after the primary surgery: A case report. (2013)
  • Author(s): Amano Y, Mandai M, Baba T, Hamanishi J, Yoshioka Y, Matsumura N, Konishi I.
  • Journal Title: Oncol Lett Volume: 6 Pages: 1241-1244
  • Peer Reviewed
• [Journal Article] A novel diagnostic criterion for lymph node metastasis in cervical cancer using multi-detector computed tomography. (2013)
  • Author(s): Yamanoi K, Matsumura N, Kido A, Baba T, Hamanishi J, Yamaguchi K, Yoshioka Y, Abou Taleb H, Togashi K, Konishi I.
  • Journal Title: Gynecol Oncol. Volume: 13 Pages: 701-707
  • Peer Reviewed
• [Journal Article] Transverse fundal uterine incision for delivery of extremely low birth-weight infants. (2013)
  • Author(s): Taga A, Kondoh E, Hamanishi J, Kawasaki K, Fujita K, Mogami H, Konishi I.
  • Journal Title: J Matern Fetal Neonatal Med Volume: 7
  • Peer Reviewed
• [Journal Article] Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers. (2013)
  • Author(s): Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
  • Journal Title: Int J Cancer Volume: 133 Pages: 2234-44
• [Journal Article] PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction. (2013)
  • Author(s): Abiko K, Mandai M, Hamanishi J, Yoshioka Y, Matsumura N, Baba T, Yamaguchi K, Murakami R, Yamamoto A, Kharma B, Kosaka K, Konishi I.
  • Journal Title: Clin Cancer Res. Volume: 19 Issue: 6 Pages: 1363-1374
  • DOI: 10.1158/1078-0432.ccr-12-2199
  • Peer Reviewed
• [Journal Article] Mandai M, Hamanishi J, Abiko K, Yoshioka Y, Konishi I. (2012)
  • Author(s): Immunological aspect of metastasis of ovarian cancer
  • Journal Title: Nihon Rinsho Volume: 4 Pages: 507-511
• [Journal Article] 【婦人科悪性腫瘍の治療開発とそのシーズ】 卵巣癌の播種・進展と免疫環境との関連分子を標的とした治療法の開発 (2012)
  • Author(s): 万代 昌紀, 濱西 潤三, 安彦 郁, 松村 謙臣, 馬場 長, 小阪 謙三, 吉岡 弓子, 小西 郁生
  • Journal Title: 産婦人科の実際 Volume: 61 Pages: 201-205
• [Presentation] 抗 PD-1 抗体(Nivolumab)を用いた医師主導治験~卵巣癌への新しい治療開発を目指して~ (2014)
  • Organizer: 第27回 京都がん研究会 ミニ レクチャー
  • Place of Presentation: 京都教育文化センター
  • Year and Date: 2014-03-07
• [Presentation] 卵巣癌治療への新たな挑戦 ~抗 PD-1 抗体(Nivolumab)を用いた医師主導治験への道標~ (2014)
  • Organizer: 第15回 京都臨床腫瘍内科懇話会
  • Place of Presentation: ウエスティン都ホテル京都
  • Year and Date: 2014-02-20
• [Presentation] 卵巣癌治療への新たな挑戦 ～抗PD-1抗体（Nivolumab）を用いた医師主導治験への道標～ (2014)
  • Author(s): 濵西潤三
  • Organizer: 第15回 京都臨床腫瘍内科懇話会
  • Place of Presentation: ウエスティン都ホテル(京都)
  • Invited
• [Presentation] 抗PD-1抗体（Nivolumab）を用いた医師主導治験 (2014)
  • Author(s): 濵西潤三
  • Organizer: 第27回 京都がん研究会
  • Place of Presentation: 京都教育文化センター
  • Invited
• [Presentation] Comprehensive analysis of immune status in ovarian cancer patients : Toward development of novel chemo-immunotherapy (2013)
  • Author(s): Junzo Hamanishi
  • Organizer: JSGO Meeting The 55th JSGO Grant Seminar
  • Place of Presentation: Kyoto
  • Year and Date: 2013-12-13
• [Presentation] がん免疫抑制・免疫疲弊の克服卵巣癌におけるがん免疫逃避機構を標的にした新しい治療戦略 ~PD-1/PD-L1 経路を標的とした新規免疫療法~ (2013)
  • Author(s): 濵西潤三
  • Organizer: 第26回日本バイオセラピィ学会学術集会総会日本バイオセラピィ学会・日本癌免疫学会合同シンポジウム
  • Place of Presentation: いわて県民情報交流センター
  • Year and Date: 2013-12-06
• [Presentation] ~生後 2 カ月からのワクチンデビューの推進と子宮頸がん予防ワクチンの適正接種に向けて~ (2013)
  • Author(s): 濵西 潤三
  • Organizer: 京都小児科・産婦人科座談会 ワクチン接種普及に向けて
  • Place of Presentation: 京都ホテルオークラ
  • Year and Date: 2013-11-14
• [Presentation] 当科における子宮頸癌への新しい取り組み (2013)
  • Author(s): 濵西潤三
  • Organizer: 京都産婦人科医会 学術研修会
  • Place of Presentation: 京都国際ホテル
  • Year and Date: 2013-11-09
• [Presentation] PD-1/PD-L1 シグナルを標的とした卵巣癌に対する免疫化学療法の基礎的検討 (2013)
  • Author(s): 濵西潤三
  • Organizer: 第51回 日本癌治療学会学術集会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2013-10-23
• [Presentation] 当科における卵巣癌に対する 新しい治療の試み ~抗 PD-1 抗体を用いた分子標的治療の臨床応用~ (2013)
  • Author(s): 濵西潤三
  • Organizer: 京都産婦人科研究会
  • Place of Presentation: 京都センチュリーホテル
  • Year and Date: 2013-10-19
• [Presentation] Symposia on Specific Tumors Develpoment of novel therapy targeting immune escape in ovarian cancer.~Immunotherapy using anti PD-1 antibody ~ Junzo Hamanishi (2013)
  • Organizer: 72nd JCA(日本癌学会)
  • Place of Presentation: Yokohama
  • Year and Date: 2013-10-03
• [Presentation] PD-1/PD-L1 経路を標的とした卵巣癌に対する新規治療の臨床応用と展望 ~ Chemo-Immunotherapy の基礎的検討~ (2013)
  • Organizer: 第17回日本がん免疫学会学術講演会
  • Place of Presentation: 宇部市
  • Year and Date: 2013-07-05
• [Presentation] 「卵巣癌におけるがん免疫逃避機構を標的にした新規治療開発」~抗 PD-1 抗体を用いた免疫療法の臨床応用~ (2013)
  • Author(s): 濱西潤三
  • Organizer: KCOG 婦人科分科会
  • Year and Date: 2013-03-22
• [Presentation] 卵巣癌における"がん免疫機構"の解明と次世代型免疫療法の臨床応用に向けて (2013)
  • Author(s): 濱西潤三
  • Organizer: 第21回 きたの産婦人科セミナー
  • Place of Presentation: 北野病院 きたのホール
  • Year and Date: 2013-01-26
• [Presentation] Induction of PD-L1 expression by cytotoxic agents through activation of NF-kB signal Junzo Hamanishi (2013)
  • Organizer: AACR Advances in Ovarian Cancer Research From Concept to Clinic -Cancer Immunology
  • Place of Presentation: J.W. Marriott Marquis Miami Miami, FL
• [Presentation] PD-1／PD-L1経路を標的とした卵巣癌に対する新規治療の臨床応用と展望 ～Chemo-Immunotherapyの基礎的検討～ (2013)
  • Author(s): 濵西潤三
  • Organizer: 第17回日本がん免疫学会学術講演会
  • Place of Presentation: ＡＮＡクラウンプラザホテル宇部(山口)
• [Presentation] “Comprehensive analysis of immune status in ovarian cancer patients:Toward development of novel chemo-immunotherapy” (2013)
  • Author(s): 濵西潤三
  • Organizer: AACR Advances in Ovarian Cancer Research From Concept to Clinic
  • Place of Presentation: Miami USA
• [Presentation] Develpoment of novel therapy targeting immune escape in ovarian cancer.~ Immunotherapy using anti PD-1 antibody ~ (2013)
  • Author(s): 濵西潤三
  • Organizer: 72nd JCA Symposia
  • Place of Presentation: パシフィコ横浜(神奈川)
• [Presentation] 当科における卵巣癌に対する 新しい治療の試み ～抗PD-1抗体を用いた分子標的治療の臨床応用～ (2013)
  • Author(s): 濵西潤三
  • Organizer: 京都産婦人科研究会 特別講演
  • Place of Presentation: 京都センチュリーホテル
  • Invited
• [Presentation] PD-1／PD-L1シグナルを標的とした卵巣癌に対する免疫化学療法の基礎的検討 (2013)
  • Author(s): 濵西潤三
  • Organizer: 第51回 日本癌治療学会学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] 卵巣癌におけるがん免疫逃避機構を標的にした新しい治療戦略 ～PD-1／PD-L1経路を標的とした新規免疫療法～ (2013)
  • Author(s): 濵西潤三
  • Organizer: 日本バイオセラピィ学会・日本癌免疫学会合同シンポジウム シンポジウム
  • Place of Presentation: いわて県民情報交流センター
  • Invited
• [Presentation] “Comprehensive analysis of immune status in ovarian cancer patients:Toward development of novel chemo-immunotherapy” (2013)
  • Author(s): Junzo Hamanishi
  • Organizer: The 3rd Biennial Meeting of ASGO / The 55th JSGO Meeting
  • Place of Presentation: ウェスティン都ホテル(京都)
• [Presentation] 婦人科領域がんの薬物治療
  • Author(s): 濵西潤三
  • Organizer: 平成２４年度 がん専門薬剤師 研修事業講義研修 集中教育講座
  • Place of Presentation: 京都大学百周年記念ホール(京都府)
• [Presentation] The analysis of local immune status in tumor site leads to new strategy for tumor immune escape of ovarian cancers 腫瘍局所の免疫状態の解析による、がん免疫逃避機構を標的とした卵巣癌の新規治療戦略
  • Author(s): 濵西潤三 万代昌紀 安彦 郁 吉岡弓子 松村謙臣 馬場 長 山口 建 奈倉道和 天野泰彰 村上 隆介 山ノ井康二 Budiman Khama Hisham Aboutaｌeb Peng Jin 小阪謙三 小西郁生
  • Organizer: 第71回日本癌学会
  • Place of Presentation: ロイトン札幌(北海道)
• [Presentation] Translational Research for Ovarian Cancer Immunotherapy for recurrent ovarian cancer, a new challenge of strategy
  • Author(s): Junzo Hamanishi
  • Organizer: ASGO the 2nd International Workshop on Gynecologic Oncology Topics 3
  • Place of Presentation: 京都東急ホテル(京都府)
• [Presentation] 当科における卵巣癌IV期症例の臨床的検討
  • Author(s): 高倉賢人 濱西潤三 松村謙臣 馬場 長 吉岡弓子 小阪謙三 万代昌紀 小西郁生
  • Organizer: 第127回 近畿産科婦人科学会学術集会
  • Place of Presentation: 大阪リーガロイヤルホテル(大阪府)
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~obgy/
• [Remarks] http://www.kuhp.kyoto-u.ac.jp/~obgy/