• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Search for the genes involved in the development of uterine leiomyoma

Research Project

Project/Area Number 24791704
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionYamaguchi University

Principal Investigator

ASADA Hiromi  山口大学, 医学部附属病院, 助教 (90526906)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords生殖医学 / 子宮筋腫
Research Abstract

Profiles of genome-wide DNA methylation and mRNA expression were investigated in leiomyomas and in myometrium with and without leiomyomas. We identified 625 genes whose DNA methylation and mRNA expression patterns differed between leiomyomas and the adjacent myometrium. We transduced 3 genes (NRG1, NR3C1 and MAPK10) of 76 genes we identified by upstream factor analysis each in lentivirus-vectors. We will transduce these vectors in immortalized human uterine smooth muscle cell and transplant them under the kidney capsule in Immunodeficient mice.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Potential Mechanisms of Aberrant DNA Hypomethylation on the X Chromosome in Uterine Leiomyomas2014

    • Author(s)
      S.Sato, R.Maekawa, Y.Yamagata, H.Asada (他5名)
    • Journal Title

      J Reprod Dev

      Volume: 60 Pages: 47-54

    • NAID

      130003381861

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of C/EBP β binding and histone acetylation status in the promoter regions for induction of IGFBP-1, PRL, and Mn-SOD by cAMP in human endometrial stromal cells2014

    • Author(s)
      I. Tamura, S. Sato, M. Okada, M. Tanabe, L. Lee, R. Maekawa, H. Asada (他 3名)
    • Journal Title

      Endocrinology

      Volume: 155 Pages: 275-286

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas.2013

    • Author(s)
      Maekawa R, Sato S, Yamagata Y, Asada H, Tamura I, Lee L, Okada M, Tamura H, Takaki E, Nakai A, Sugino N
    • Journal Title

      PLoS One

      Volume: 8 Issue: 6 Pages: e66632-e66632

    • DOI

      10.1371/journal.pone.0066632

    • NAID

      120005652007

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in histone modification and DNA methylation of the StAR and Cyp19a1 promoter regions in granulosa cells undergoing luteinization during ovulation in female rats2013

    • Author(s)
      L. lee, H. Asada (他8名)
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 458-470

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of IGFBP-1 expression by cAMP is associated with histone acetylation status of the oromoter region in human endometrial stromal cells2012

    • Author(s)
      I. Tamura, H. Asada (他7名)
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 5612-5621

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 子宮筋腫における X 染色体の低メチル化変異機構2013

    • Author(s)
      佐藤 俊, 前川 亮, 山縣芳明, 浅田裕美, 田村 功, 李 理華, 岡田真紀, 田村博史, 杉野法広
    • Organizer
      第18回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京.シェーンバッハ・サボー
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮筋腫のゲノムワイドDNAメチル化解析2012

    • Author(s)
      前川 亮, 山縣芳明, 浅田裕美, 田村 功, 李 理華, 田邊 学, 田村博史, 杉野法広
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      愛知.名古屋国際会議場
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮筋腫のゲノムワイドDNAメチル化解析2012

    • Author(s)
      前川 亮、山縣 芳明、田村 功、李 理華、浅田 裕美、杉野 法広
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸(神戸ポートピアホテル)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi