The underlying clinical study on production mechanism of the new endometriosis marker
| Project/Area Number |
24791707
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University |
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Principal Investigator |
NABETA Motowo 愛媛大学, 医学部附属病院, 講師 (80444751)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 子宮内膜症 / 抗PDIK1L自己抗体 / 血清診断 / 自己抗体 |
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| Research Abstract |
[purpose] We searched for an endometriotic new serodiagnosis marker.[method] We established the ELISA method and analyzed it.We analyzed the tissue manifestation nature of the PDIK1L protein by immunity tissue staining.
The diagnosability (58.1% of sensitivity, specificity 84.1%) of the antiPDIK1L self antibody titers was clearly superior in serum for the CA125 which was an existing serum marker. [results and discussion] Furthermore, we were able to put up the sensitivity of the endometriosis diagnosis to 73.0% by using both together. As a result of having analyzed it by immunity tissue staining, we were strong, and manifestation of PDIK1L was found in endometriosis tissue and developed in 94.7% of endometriosis cases.[conclusions] We found antiPDIK1L autoantibody as a new method of the endometriosis diagnosis.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Concurrent chemoradiotherapy with nedaplatin in patients with stage IIA to IVA cervical carcinoma2013
Author(s)
Fujioka T, Yasuoka T, Koizumi M, Tanaka H, Hashimoto H, Nabeta M, Koizumi K, Matsubara Y, Hamada K, Matsubara K, Katayama T, Nawa A
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Journal Title
Mol Clin Oncol
Volume: 1(1)
Pages: 165-170
Related Report
Peer Reviewed
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[Journal Article] Concurrent chemoradiotherapy with nedaplatin in patients with stage IIA to IVA cervical carcinoma.2013
Author(s)
Fujioka, T., Yasuoka, T., Koizumi, M., Tanaka, H., Hashimoto, H., Nabeta, M., Koizumi, K., Matsubara, Y., Hamada, K., Matsubara, K., Katayama, T., Nawa, A.
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Journal Title
Molecular and clinical oncology
Volume: 1
Issue: 1
Pages: 165-170
DOI
Related Report
Peer Reviewed
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[Presentation] 愛媛大学医学部附属病院における不妊診療の現況2013
Author(s)
鍋田基生, 伊木朱有美, 佐保知織, 安岡稔晃, 小泉絵理, 井上彩, 内倉友香, 田中寛希, 森美妃, 高木香津子, 近藤恵美, 橋本尚, 小泉雅江, 松元隆, 松原裕子, 濱田雄行, 藤岡徹, 松原圭一, 那波明宏
Organizer
第22回愛媛県産婦人科医会臨床集談会
Place of Presentation
松山市
Year and Date
2013-11-23
Related Report
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[Presentation] 子宮内膜症に特異的な自己抗原タンパク質 PDIK1L の組織発現性検討2013
Author(s)
鍋田基生, 伊木朱有美, 佐保知織, 小泉絵理, 井上彩, 森美妃, 高木香津子, 近藤恵美, 小泉雅江, 濱田雄行, 松原圭一, 草薙康城, 那波明宏
Organizer
第58回日本生殖医学会総会・学術講演会
Place of Presentation
神戸市
Related Report
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[Presentation] Analysis of the anti-STX5 autoantibody identified as a new serum marker for endometriosis2013
Author(s)
Nabeta M, Iki A, Hashimoto H, Koizumi M, Matsubara Y, Hamada K, Fujioka T, Matsubara K, Kusanagi Y, Nawa A
Organizer
Annual meeting of ESHRE (European Society of Human Reproduction and Embryology)
Place of Presentation
London, United Kingdom
Related Report
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[Presentation] Analysis of the anti-STX5 autoantibody identified as a new serum marker for endometriosis.2013
Author(s)
Nabeta M, Iki A, Hashimoto H, Koizumi M, Matsubara Y, Hamada K, Fujioka T, Matsubara K, Kusanagi Y, Nawa A.
Organizer
Annual meeting of ESHRE (European Society of Human Reproduction and Embryology)
Place of Presentation
London, UK
Related Report
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