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FGFR2IIIc related to carcinogenesis and as a potential molecular target for endometrioid adenocarcinoma

Research Project

Project/Area Number 24791725
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNippon Medical School

Principal Investigator

PENG Wei-Xia  日本医科大学, 医学部, 講師 (00535700)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords類内膜腺癌 / FGFR2 IIIc / carcinogenesis / 子宮類内膜腺癌 / FGFR2IIIc / 子宮内膜癌 / 子宮内膜増殖症 / 発癌 / 分化度 / Grade / FGFR2IIIc
Outline of Final Research Achievements

We identified roles for Fibroblast Growth Factor Receptor 2 (FGFR2)isoform IIIc in EEC carcinogenesis and demonstrated its diagnostic and prognostic values in EEC. Compared to high expression in atypical hyperplasia, Grade 1 (G1), and Grade 2 (G2) EEC tissues, Grade 3 (G3) EEC tissue showed low FGFR2IIIc expression (P <0.05). These results suggest that altered FGFR2IIIc expression plays an important role in EEC carcinogenesis. Some G3 EECs may develop through different carcinogenic processes than G1 and G2 EECs.
With the aim of identifying diagnostic and treatment biomarkers for EEC, we analyzed protein expression of EECs using proteomix. Although we could not identify high FGFR2IIIc expression in EEC tissues, 14 proteins showed upregulation in G3 EECs comapared to G1 and G2 EECs. These results may help in the identification of novel potential therapeutic target in EECs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (21 results)

  • [Journal Article] Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma2015

    • Author(s)
      Takaya A, Peng WX, Ishino K, Kudo M, Yamamoto T, Wada R, Takeshita T, Naito Z
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 4 Pages: 1573-81

    • DOI

      10.3892/ijo.2015.2858

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rare case of myxoid liposarcoma of the adult foot diagnosed using fine needle aspiration cytology (FNAC)2015

    • Author(s)
      Kure S, Peng WX, Kudo M, Matsubara M, Tsunoda T, Naito Z
    • Journal Title

      Pathol Lab Med Int

      Volume: 7 Pages: 1-5

    • DOI

      10.2147/plmi.s72042

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered expression of fibroblast growth factor receptor 2 isoform IIIc: relevance to endometrioid adenocarcinoma carcinogenesis and histological differentiation2014

    • Author(s)
      Peng WX, Kudo M, Fujii T, Teduka K, Naito Z.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 7 Pages: 1069-76

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altered expression of fibroblast growth factor receptor 2 isoform IIIc: relevance to endometrioid adenocarcinoma carcinogenesis and histological differentiation2014

    • Author(s)
      Peng WX, Kudo M, Fujii T, Teduka K, Naito Z.
    • Journal Title

      International Journal of Clinical and Experimental Pathology

      Volume: 7 Pages: 1069-1076

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of protein expression regulated by lumican in PANC‑1 cells using shotgun proteomics2013

    • Author(s)
      Yamamoto T, Kudo M, Peng WX, Naito Z
    • Journal Title

      Oncol Rep.

      Volume: 30(4) Issue: 4 Pages: 1609-21

    • DOI

      10.3892/or.2013.2612

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nodular fasciitis in the parotid gland: A case report and review of the literature2013

    • Author(s)
      Wei-Xia Peng, Mitsuhiro Kudo, Tetsushi Yamamoto, Shunta Inai, Takenori Fujii, Kiyoshi Teduka, Kiyoko Kawahara, Zenya Naito
    • Journal Title

      Diagnostic Cytopathology

      Volume: in press Issue: 9 Pages: 829-833

    • DOI

      10.1002/dc.22983

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Serous adenocarcinoma arising in an endometrial polyp: a case report2015

    • Author(s)
      Wei-Xia Peng, Takenori Fujii, Kiyoshi Teduka, Keisuke Kurose, Kousuke Ishino, Mitsuhiro Kudo, Ryuichi Wada, Zenya Naito
    • Organizer
      第22回タイ-日本細胞診ワークショップ
    • Place of Presentation
      タイ王国・プーケット
    • Year and Date
      2015-01-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] p16-positive gastric type adenocarcinoma in uterine cervix2014

    • Author(s)
      Wei-Xia Peng, Mitsuhiro Kudo, Takenori Fujii, Kiyoshi Teduka, Akane Takaya, Keisuke Kurose, Koichi Yoneyama, Zenya Naito
    • Organizer
      第18回日韓台婦人科病理合同会議
    • Place of Presentation
      台湾・台北市
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] FFPE組織を用いた卵巣癌プロテオーム解析による新規バイオマーカーの探索2014

    • Author(s)
      高屋茜, 彭為霞, 紺野亜希子, 高田英志, 藤井雄文, 手塚潔, 石野孔祐, 山本哲志, 工藤光洋, 内藤善哉
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gastric type adenocarcinoma in a patient with Peutz Jeghers syndrome2014

    • Author(s)
      Peng WX, Fujii T, Teduka K, Kurose K, Yoneyama K, Naito Z
    • Organizer
      The 21th Thai-Japanese Workshop In Diagnostic Cytopathology
    • Place of Presentation
      Chiang Mai, Thailand
    • Related Report
      2013 Research-status Report
  • [Presentation] Peutz-Jeghers type polyp with malignant transformation in uterine cervix2013

    • Author(s)
      Peng WX, Kudo M, Fujii T, Teduka K, Kurose K, Naito Z
    • Organizer
      The 18th International Congress of Cytology
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Research-status Report
  • [Presentation] A case in which cytology features help the diagnosis of the atypical polypoid adenomyoma2013

    • Author(s)
      Takaya A, Peng WX, Sato A, Matsubara M, Kamoi S, Naito Z
    • Organizer
      The 18th International Congress of Cytology
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Research-status Report
  • [Presentation] 多発性骨髄腫の治療中に内頚動脈真菌性血栓症による脳梗塞の一剖検例2013

    • Author(s)
      彭為霞、工藤光洋、藤井雄文、手塚潔、内藤善哉
    • Organizer
      第59回日本病理学会 秋期特別総会
    • Place of Presentation
      山梨
    • Related Report
      2013 Research-status Report
  • [Presentation] ホルマリン固定パラフィン包埋肝細胞癌組織を用いたプロテオーム解析2013

    • Author(s)
      工藤光洋、高田英志、彭為霞、山本哲志、藤井雄文、手塚潔、内藤善哉
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 上皮性卵巣癌のホルマリン固定パラフィン包埋組織からの蛋白質プロテオーム解析2013

    • Author(s)
      高屋茜、彭為霞、紺野亜希子、高田英志、手塚潔、藤井雄文、工藤光洋、竹下俊行、内藤善
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝細胞癌ホルマリン固定パラフィン包埋組織を用いたプロテオーム解析による新規バイオマー探索2013

    • Author(s)
      高田英志、山本哲志、工藤光洋、彭為霞、手塚潔、藤井雄文、上田純志、内田英二、内藤善
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] FFPE 切片を用いたケラトアカントーマのプロテオーム解析2013

    • Author(s)
      紺野亜希子、工藤光洋、安齋眞一、山本哲志、藤井雄文、手塚潔、彭為霞、川名誠司、内藤善哉
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ホルマリン固定パラフィン包埋大腸がん組織を用いた新規診断マーカーの探索2013

    • Author(s)
      山本哲志、工藤光洋、彭為霞、高田英志、三田村邦子、多賀淳、内藤善哉
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮類内膜腺癌及び前癌病変におけるFGFR2IIIcの役割解明2013

    • Author(s)
      彭為霞、工藤光洋、山本哲志、藤井雄文、手塚潔、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝細胞癌にてダウンレギュレートしたタンパク質のホルマリン固定パラフィン包埋組織からのプロテオーム解析2013

    • Author(s)
      工藤光洋、山本哲志、高田英志、彭為霞、藤井雄文、手塚潔、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 耳下腺に発生した脂腺腺腫および脂腺型リンパ腺腫の2例2013

    • Author(s)
      呉壮香、彭為霞、恩田宗彦、許田典男、酒主敦子、中溝宗永、関根久遠、北山康彦、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 卵巣癌における膜結合型ムチン及びHer2の免疫組織化学的検討2013

    • Author(s)
      高屋茜、彭為霞、紺野亜希子、高田英志、藤井雄文、手塚潔、山本哲志、工藤光洋、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] ホルマリン固定パラフィン包埋組織ブロックを用いた肝細胞癌のプロテオミクス解析2013

    • Author(s)
      高田英志、山本哲志、工藤光洋、彭為霞、藤井雄文、手塚、内田英二、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] ケラントアカントーマのホルマリン固定パラフィン包埋組織によるプロテオーム解析2013

    • Author(s)
      紺野亜希子、工藤光洋、山本哲志、藤井雄文、手塚潔、彭為霞、安斎眞一、川名誠司、内藤善哉
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Hamartomatous endocervical polyp with malignant transformation in Peutz-Jeghers syndrome patient2013

    • Author(s)
      Wei-Xia Peng, Mitsuhiro Kudo, Tetsushi Yamamoto, Takenori Fujii, Kiyoshi Teduka, Keigo Mitsui, Keisuke Kurose, Seiryu Kamoi, Zenya naito
    • Organizer
      The 20th Thai-Japanese Workshop In Diagnostic Cytopathology
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] 40代に発生した卵巣癌肉腫の一例2012

    • Author(s)
      彭為霞、佐藤杏月、高屋茜、釜口晴美、土屋眞一、内藤善哉
    • Organizer
      第51回日本臨床細胞学会秋期大会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
  • [Presentation] A case of nodular fasciitis in parotid gland region2012

    • Author(s)
      Wei-Xia Peng, Mitsuhiro Kudo, Tetsushi Yamamoto, Shunta Inai, Takenori Fujii, Kiyoshi Teduka, Kiyoko Kawahara, Zenya Naito
    • Organizer
      第101回 日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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