CD24 expression is correlated with an EMT (Epithelial-Mesenchymal-Transition) status in endometrial cancer

• Project/Area Number: 24791727
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka Medical College
• Principal Investigator: TANAKA Yoshimichi 大阪医科大学, 医学部, 助教 (10625502)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 子宮内膜癌 / EMT / CD24 / 子宮体癌 / E-cadherin / snail / slug

Research Abstract

We clarified that reduced E-cadherin and nuclear expression of Snail and Slug have a prognositic impact in endometrial cancer. Moreover CD24 expression is associated with malignant potential and correlated with EMT status in endometrial cancer.

Research Products

• [Journal Article] Prognostic impact of EMT (Epitherial Mesenchymal Transition ) related protein expression in endometrial cancer (2013)
  • Author(s): Tanaka Y, Terai Y, Kawagushi H, Takai M, Fujiwara S, Yu S, Tsunetoh S, Sasaki H, Kanemura M, Tanabe A, Ohmichi M
  • Journal Title: Cancer Biol Ther Volume: 14 Pages: 13-9
  • Peer Reviewed
• [Journal Article] Novel para-aortic lymphadenectomy technique for gynecological malignancies prevents postoperative bowel obstruction (2013)
  • Author(s): Terai Y, Sasaki H, Tsunetoh S, Tanaka Y, Yoo S, Fujiwara S, Kanemura M, Ohmichi M
  • Journal Title: J Obstet Gynaecol Res Volume: 39 Pages: 849-54
  • Peer Reviewed
• [Journal Article] Prognostic impact of EMT(epithelial-mesenchymal-transition)-related protein expression in endometrial cancer (2013)
  • Author(s): Tanaka Yoshimichi
  • Journal Title: Cancer Biology & Therapy Volume: 14(1) Pages: 13-19
  • Peer Reviewed
• [Journal Article] Prognostic impact of EMT (Epitherial Mesenchymal Transition ) related protein expression in endometrial cancer. (2013)
  • Author(s): Tanaka Yoshimichi et al
  • Journal Title: Cancer Biology and Therapy. Volume: 14(1) Pages: 13-19
  • Peer Reviewed
• [Journal Article] Mucinous adenocarcinoma of the intestinal type arising from mature custic teratoma of the ovary : a rare case report and review of the literature (2012)
  • Author(s): Takai M, Kanemura M, Kawagushi H, Fujiwara S, Yoo S, Tanaka Y, Tsunetoh S, Terai Y, Yamada T, Ohmichi M
  • Journal Title: J ovarian Res Volume: 5 Pages: 41-4
  • Peer Reviewed
• [Journal Article] GPR30 regurates EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer (2012)
  • Author(s): Fujiwara S, Terai Y, Kawagushi H, Takai M, Yoo S, Tanaka Y, Tanaka T, Tsunetoh S, Sasaki H, Kanemura M, Tanabe A, Yamashita Y, Ohmichi M
  • Journal Title: J ovarian Res Volume: 5 Pages: 35-42
  • Peer Reviewed
• [Presentation] Epitherial Mesenchymal Transition(EMT) in endometrial cancer (2013)
  • Author(s): 田中良道
  • Organizer: アジア婦人科腫瘍学会
  • Place of Presentation: 京都
  • Year and Date: 2013-11-20
• [Presentation] 若年子宮内膜癌・子宮内膜異型増殖症に対するMPA 療法の治療成績 (2013)
  • Author(s): 田中良道
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都
• [Presentation] 若年子宮内膜癌・子宮内膜異型増殖症に対するMPA 療法の治療成績 (2013)
  • Author(s): 田中良道
  • Organizer: 日本婦人科腫瘍学会
  • Place of Presentation: 東京
• [Presentation] 妊娠中のCIN から初期子宮頸癌の診断と治療 (2012)
  • Author(s): 田中良道
  • Organizer: 日本癌治療学会
  • Place of Presentation: 横浜
• [Presentation] 進行卵巣癌NAC 前の診断における腹腔鏡下手術の有用性について (2012)
  • Author(s): 田中良道
  • Organizer: 近畿産婦人科学会
  • Place of Presentation: 京都
• [Presentation] 卵巣癌・腹膜癌NAC 症例における診断目的の腹腔鏡下手術の有用性について (2012)
  • Author(s): 田中良道
  • Organizer: JSAWI
  • Place of Presentation: 兵庫
• [Presentation] 子宮頸部初期病変治療後のピトフォール (2012)
  • Author(s): 田中良道
  • Organizer: 日本婦人科腫瘍学会
  • Place of Presentation: 東京
• [Presentation] 子宮体部移行上皮癌の1 例 (2012)
  • Author(s): 田中良道
  • Organizer: 日本臨床細胞学会
  • Place of Presentation: 千葉
• [Presentation] 子宮体癌におけるEMT マーカーとしてのCD24 の有用性 (2012)
  • Author(s): 田中良道
  • Organizer: 日本産婦人科学会
  • Place of Presentation: 神戸
• [Presentation] Prognostic impact of EMT(Epitherial Mesancymal Transition) related protein expression in endometrial cancer (2012)
  • Author(s): 田中良道
  • Organizer: AACR
  • Place of Presentation: シカゴ
• [Presentation] 子宮体癌におけるEMTのマーカーとしてのCD24の有用性
  • Author(s): 田中良道
  • Organizer: 日本婦人科がん分子標的学会
  • Place of Presentation: 奈良
• [Presentation] Prognostic impact of EMT (Epitherial Mesenchymal Transition ) related protein expression in endometrial cancer.
  • Author(s): Tanaka Yoshimichi
  • Organizer: AACR
  • Place of Presentation: シカゴ（アメリカ）
• [Presentation] 子宮体癌におけるEMTマーカーとしてのCD24の有用性
  • Author(s): 田中 良道
  • Organizer: 日本産婦人科学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 上皮間葉転換（EMT）を介した浸潤・転移の制御を目指して CD24の機能解析
  • Author(s): 中村 起代子
  • Organizer: 日本産婦人科学会学術集会
  • Place of Presentation: ロイトン札幌（北海道）
• [Book] 産科と婦人科 (2013)
  • Author(s): 田中良道
  • Total Pages: 3
  • Publisher: 診断と治療社