A role of progesterone receptor in uterine smooth muscle as human parturition

Research Project

Project/Area Number	24791728
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Obstetrics and gynecology
Research Institution	Osaka Medical College
Principal Investigator	FUJITA Daisuke 大阪医科大学, 医学部, 講師 (90411371)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	プロゲステロン / オキシトシン / バゾプレッシン / GPR30 / 陣痛発来 / ピトレシン / 妊娠子宮 / 子宮収縮 / エストロゲン
Outline of Final Research Achievements	Our objective was to determine how expression of Progesterone receptor and GPR30, vasopressin receptor change in human uterine smooth muscle using real time PCR.It was suggested that PR and GPR30,vasopressin V1α receptor play a important role in uterine contraction and human parturition.The expression of the vasopressin V1α receptor in uterine smooth muscle was evaluated by immunohistochemistry. As a result,patients in placenta previa underwent the local injection of a vasopressin solution into the placental implantation site after placental delivery. The mean estimated blood loss was significantly lower in the vasopressin group than in the control group. The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.