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A role of progesterone receptor in uterine smooth muscle as human parturition

Research Project

Project/Area Number 24791728
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

FUJITA Daisuke  大阪医科大学, 医学部, 講師 (90411371)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsプロゲステロン / オキシトシン / バゾプレッシン / GPR30 / 陣痛発来 / ピトレシン / 妊娠子宮 / 子宮収縮 / エストロゲン
Outline of Final Research Achievements

Our objective was to determine how expression of Progesterone receptor and GPR30, vasopressin receptor change in human uterine smooth muscle using real time PCR.It was suggested that PR and GPR30,vasopressin V1α receptor play a important role in uterine contraction and human parturition.The expression of the vasopressin V1α receptor in uterine smooth muscle was evaluated by immunohistochemistry. As a result,patients in placenta previa underwent the local injection of a vasopressin solution into the placental implantation site after placental delivery. The mean estimated blood loss was significantly lower in the vasopressin group than in the control group. The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Local injection of vasopressin reduces the blood loss during cesarean section in placenta previa.2014

    • Author(s)
      Kato S, Tanabe A, Kanki K, Suzuki Y, Sano T, Tanaka K, Fujita D, Terai Y, Kamegai H, Ohmichi M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40(5) Pages: 1249-56

    • DOI

      10.1111/jog.12356

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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