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The role of cleaved prolactin in pregnancy complicated with heart disease

Research Project

Project/Area Number 24791734
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KAMIYA Chizuko  独立行政法人国立循環器病研究センター, 病院, 医師 (10551301)

Co-Investigator(Renkei-kenkyūsha) IKEDA Tomoaki  三重大学医学部, 産科婦人科学教室, 教授 (80202894)
MICHIYO Ishida  明治大学, 農学部生命科学科生体機構学研究室, 特任講師 (20445860)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords循環器疾患 / 妊娠 / プロラクチン / 心疾患 / 妊娠・出産 / 心筋症 / 妊娠出産
Outline of Final Research Achievements

The aim of the study was to analyze the role of cleaved prolactin, known as an antiangiogenic agent, in pregnancy complicated with heart disease, by both clinical and basic research. The amount of cleaved prolactin during antepartum and postpartum was significantly increased in women with heart disease compared with those in the healthy controls. Postpartum women with heart disease who did breast feeding tended to experience a cardiovascular event more often than those who did not breast feed.
The cardiac weight of model mice was increased the most during lactation. Histological stain revealed that cleaved prolactin existed in both capillary vessels and cardiomyocytes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012

All Journal Article (10 results) Presentation (10 results) (of which Invited: 4 results) Book (3 results)

  • [Journal Article] 妊娠に伴う循環器疾患2014

    • Author(s)
      神谷千津子、村岡温子(企画)
    • Journal Title

      心臓

      Volume: 46(11) Pages: 1420-1424

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 妊産婦循環器疾患治療の注意点2014

    • Author(s)
      神谷千津子
    • Journal Title

      循環器内科

      Volume: 75(2) Pages: 165-171

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Journal Article] 産褥(周産期)心筋症2014

    • Author(s)
      神谷千津子、池田智明
    • Journal Title

      産婦人科の実際

      Volume: 63(2) Pages: 233-239

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Journal Article] 先天性心疾患の妊娠出産における周産期管理の問題点と対応:分娩方法、分娩時管理、産後管理2013

    • Author(s)
      神谷千津子
    • Journal Title

      Heart View

      Volume: 17(9) Pages: 1-2

    • Related Report
      2013 Research-status Report
  • [Journal Article] Safty and Efficary of implantable Cardioverter-Defibrillator During Pregnancy and After Delivery2013

    • Author(s)
      Miyoshi T, Kamiya C
    • Journal Title

      Circulation Journal

      Volume: 77(5) Pages: 1166-1170

    • Related Report
      2013 Research-status Report
  • [Journal Article] 妊娠と心疾患2013

    • Author(s)
      神谷千津子
    • Journal Title

      心エコー

      Volume: 14(3) Pages: 254-263

    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Journal Article] 周産期心筋症を識る-切断プロラクチンの役割2013

    • Author(s)
      神谷千津子
    • Journal Title

      Heart View

      Volume: 17(3) Pages: 84-88

    • Related Report
      2013 Research-status Report
  • [Journal Article] Pregnancy-Related Acute Myocardial Infarction in Japan2013

    • Author(s)
      Chuzuko A Kamiya
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 3 Pages: 606-607

    • DOI

      10.1253/circj.CJ-13-0063

    • NAID

      10031138946

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Research-status Report
  • [Journal Article] 周産期(産褥)心筋症と診断マーカー 妊産婦死亡2013

    • Author(s)
      神谷千津子
    • Journal Title

      産婦人科の実際

      Volume: 61(9) Pages: 1311-1318

    • Related Report
      2012 Research-status Report
  • [Journal Article] 周産期心筋症を識る-切断プロラクチンの役割-2012

    • Author(s)
      神谷千津子
    • Journal Title

      Heart View

      Volume: 17(3) Pages: 84-88

    • Related Report
      2012 Research-status Report
  • [Presentation] 周産期心筋症~最近の基礎・臨床研究の成果から~2014

    • Author(s)
      神谷千津子
    • Organizer
      第18回日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 心疾患患者の妊娠出産の管理はどのようにするか2014

    • Author(s)
      神谷千津子
    • Organizer
      第78回日本循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 妊娠中の心機能モニタリング2014

    • Author(s)
      神谷千津子
    • Organizer
      第78回日本循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Successful Aortic Replacements in Pregnant Women with Marfan Syndrome2014

    • Author(s)
      Chizuko A Kamiya
    • Organizer
      The 3rd International Congress on Cardiac Problems in Pregnancy
    • Place of Presentation
      Italia Venice
    • Related Report
      2013 Research-status Report
  • [Presentation] 成人先天性心疾患を持つ女性の妊娠・出産~診療体制の変遷と今後の課題~2013

    • Author(s)
      神谷千津子、吉松淳
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 周産期心筋症における抗プロラクチン療法の有効性についての研究:全国多施設前向き共同研究2013

    • Author(s)
      神谷千津子
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      北海道
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Outcomes of Peripartum Cardiomyopathy with and without Anti-prolactin Therapy: Progress Report of the Japanese Nationwide Prospective Survey2013

    • Author(s)
      神谷 千津子
    • Organizer
      第77回日本循環器学会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 心疾患合併妊娠 ~国立循環器病研究センターの症例から~2012

    • Author(s)
      神谷 千津子
    • Organizer
      第7回国立循環器病研究センター 周産期サマーセミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Three Cases of “Suspected Peripartum Cardiomyopathy” Patients with Previous History of Heart Disease Who Had Been Observed Normal Left Ventricular Function2012

    • Author(s)
      Chizuko Kamiya
    • Organizer
      The Second International Congress on Cardiac Problems in Pregnancy
    • Place of Presentation
      ドイツ(ベルリン)
    • Related Report
      2012 Research-status Report
  • [Presentation] 周産期心筋症における心機能予後に影響する因子についての検討2012

    • Author(s)
      神谷 千津子
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Book] 産科診療Q&A2015

    • Author(s)
      板倉敦夫
    • Total Pages
      264
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 今日の治療指針2015

    • Author(s)
      山口徹他
    • Total Pages
      1973
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 心臓外科Knack&Pitfalls ワンポイントアドバイス周産期(産褥性)心筋症による心不全2012

    • Author(s)
      髙本眞一編、神谷千津子
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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