Possibility of EMMPRIN as a therapeutic target in head and neck cancer

• Project/Area Number: 24791740
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Akita University
• Principal Investigator: SUZUKI SHINSUKE 秋田大学, 医学部, 講師 (90312701)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癌 / 頭頸部癌 / EMMPRIN / CD147 / S100A9 / リンパ節転移 / 細胞内シグナル

Outline of Final Research Achievements

This study revealed that EMMPRIN/CD147 mediates HNSCC migration by its interaction with S100A9. In addition, the results showed anti-tumor effect of EMMPRIN/CD147 inhibition, and also suggest the EMMPRIN inhibition increases anti-tumor effects of EGFR targeting in head and neck cancer. An analysis based on clinial samples showed that EMMPRIN expression significantly correlated with lymph node metastases of stage I and II squamous cell carcinoma of the tongue.

Research Products

• [Journal Article] Stage I・II舌扁平上皮癌の頸部リンパ節転移とCD147/EMMPRINの発現に関する検討 (2015)
  • Author(s): 鈴木真輔，本田耕平，南條博，川村 学，石川和夫
  • Journal Title: 日本頭頸部癌学会雑誌 Volume: 未定
  • NAID: 130005070001
  • Peer Reviewed
• [Journal Article] Combined inhibition of EMMPRIN and epidermal growth factor receptor prevents the growth and migration of head and neck squamous cell carcinoma cells. (2013)
  • Author(s): Suzuki S, Ishikawa K.
  • Journal Title: Int J Oncol Volume: 44 Issue: 3 Pages: 912-917
  • DOI: 10.3892/ijo.2013.2238
  • Peer Reviewed
• [Journal Article] Cyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma (2012)
  • Author(s): Masafumi Takahashi, Shinsuke Suzuki, Kazuo Ishikawa
  • Journal Title: Oncology Report Volume: 27 Pages: 198-203
  • DOI: 10.3892/or.2011.1474
  • Peer Reviewed
• [Presentation] S100A9 induces head and neck squamous cell carcinoma migration through its interaction with CD147/EMPRIN (2014)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: IFHNOS 5th WORLD CONGRESS AND AHNS ANNUAL Mtg
  • Place of Presentation: New York
  • Year and Date: 2014-07-27 – 2014-07-30
• [Presentation] 舌扁平上皮癌T1、T2症例における頸部リンパ節転移とCD147/EMMPRINの発現ついて (2014)
  • Author(s): 鈴木真輔, 石川和夫
  • Organizer: 第38回 頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 頭頸部扁平上皮癌におけるS100A9とCD147/EMMPRINの役割 (2014)
  • Author(s): 鈴木真輔, 石川和夫
  • Organizer: 第115回 日本耳鼻咽喉科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] S100A9 induces head and neck squamous cell carcinoma migration through its interaction with CD147/EMPRIN (2014)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: 5th WORLD CONGRESS - IFHNOS AND ANNUAL AHNS MEETING
  • Place of Presentation: New York
• [Presentation] 舌扁平上皮癌T1、T2症例における頸部リンパ節転移とCD147/EMMPRINの発現ついて (2014)
  • Author(s): 鈴木真輔, 石川和夫
  • Organizer: 第38回 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Combined inhibition of EMMPRIN and epidermal growth factor receptor abrogates growth and migration of head and neck squamous cell carcinoma cells (2013)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: AACR Annual Meeting
  • Place of Presentation: Washington DC
• [Presentation] 頭頸部扁平上皮癌の細胞増殖制御に対するEMMPRINとEGFRの阻害効果 (2013)
  • Author(s): 鈴木真輔, 石川和夫
  • Organizer: 第114回 日本耳鼻咽喉科学会総会
  • Place of Presentation: 札幌
• [Presentation] 中咽頭扁平上皮癌におけるEMMPRINの発現と予後に関する検討 (2013)
  • Author(s): 鈴木真輔、本田耕平、石川和夫
  • Organizer: 第37回 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Combined inhibition of EMMPRIN and epidermal growth factor receptor abrogates growth and migration of head and neck squamous cell carcinoma cells (2013)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: AACR Annual Meeting 2013
  • Place of Presentation: Washinton DC
• [Presentation] 中咽頭扁平上皮癌におけるEMMPRINの発現と予後に関する検討 (2013)
  • Author(s): 鈴木真輔、本田耕平、石川和夫
  • Organizer: 第37回 頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 頭頸部扁平上皮癌の細胞増殖制御に対するEMMPRINとEGFRの阻害効果 (2013)
  • Author(s): 鈴木真輔、石川和夫
  • Organizer: 第114回 日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 札幌
• [Presentation] EMMPRIN はEGFRの腫瘍形成を媒介する (2012)
  • Author(s): 鈴木真輔、石川和夫
  • Organizer: 第36回 頭頸部癌学会
  • Place of Presentation: 松江市
• [Presentation] EMMPRIN mediates EGFR-induced HNSCC MMP-9 expression and invasion (2012)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: 8th International Conference on Head and Neck Cancer
  • Place of Presentation: Tronto