Possibility of EMMPRIN as a therapeutic target in head and neck cancer
| Project/Area Number |
24791740
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / 頭頸部癌 / EMMPRIN / CD147 / S100A9 / リンパ節転移 / 細胞内シグナル |
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| Outline of Final Research Achievements |
This study revealed that EMMPRIN/CD147 mediates HNSCC migration by its interaction with S100A9. In addition, the results showed anti-tumor effect of EMMPRIN/CD147 inhibition, and also suggest the EMMPRIN inhibition increases anti-tumor effects of EGFR targeting in head and neck cancer. An analysis based on clinial samples showed that EMMPRIN expression significantly correlated with lymph node metastases of stage I and II squamous cell carcinoma of the tongue.
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Report
(4 results)
Research Products
(16 results)
