Development of new treatments for nasal diseases through novel target molecules
| Project/Area Number |
24791742
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 慢性副鼻腔炎 / アレルギー性鼻炎 / ペンドリン / ペリオスチン |
|---|
| Outline of Final Research Achievements |
Several factors contribute to pathologies such as excessive mucus production and mucosal edema, leading to nasal discharge and obstruction in inflammatory nasal disorders. These pathological conditions might be precipitated by the actions of molecules such as pendrin and periostin. Production of these molecules is induced by IL-13 in airway epithelial cell cultures. Production of these molecules is upregulated in inflammatory nasal disorders.
We also studied the correlation between serum periostin concentration and severity of chronic sinusitis. Periostin may be employed as a biomarker of disease activity and severity of inflammatory nasal disorders.
|
Report
(4 results)
Research Products
(12 results)
