Development of new treatments for nasal diseases through novel target molecules

• Project/Area Number: 24791742
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Yamagata University
• Principal Investigator: ISHIDA Akihiro 山形大学, 医学部, 非常勤講師 (00361246)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 慢性副鼻腔炎 / アレルギー性鼻炎 / ペンドリン / ペリオスチン

Outline of Final Research Achievements

Several factors contribute to pathologies such as excessive mucus production and mucosal edema, leading to nasal discharge and obstruction in inflammatory nasal disorders. These pathological conditions might be precipitated by the actions of molecules such as pendrin and periostin. Production of these molecules is induced by IL-13 in airway epithelial cell cultures. Production of these molecules is upregulated in inflammatory nasal disorders.
We also studied the correlation between serum periostin concentration and severity of chronic sinusitis. Periostin may be employed as a biomarker of disease activity and severity of inflammatory nasal disorders.

Research Products

• [Journal Article] Expressions and roles of periostin in otolaryngological diseases. (2014)
  • Author(s): Ohta N, Ishida A, et al.
  • Journal Title: Allergology International Volume: 63 Pages: 171-180
  • NAID: 130004477218
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expressions and Roles of Periostin in Otolaryngological Diseases (2014)
  • Author(s): Ohta N, Ishida A et al.
  • Journal Title: Allergology International Volume: Epub ahead of print
  • NAID: 130004477218
  • Peer Reviewed
• [Journal Article] ペンドリン・ペリオスチンとアレルギー性鼻炎 (2013)
  • Author(s): 石田晃弘 太田伸男
  • Journal Title: アレルギー・免疫 Volume: (Vol.20 No.5) Pages: 58-64
• [Journal Article] Roles of TGF-beta and periostin in fibrosclerosis in patients with IgG4-related diseases. (2013)
  • Author(s): Ohta N, Kurakami K, Ishida A, Furukawa T, Suzuki Y, Aoyagi M, Matsubara A, Izuhara K, Kakehara S.
  • Journal Title: Acta Oto-laryngologica Volume: 133 Issue: 12 Pages: 1322-1327
  • DOI: 10.3109/00016489.2013.831187
  • Peer Reviewed
• [Journal Article] Expression of Pendrin and Periostin in Allergic Rhinnitis and Chronic Rhinosinusitis (2012)
  • Author(s): Akihiro Ishida, Nobuo Ota, Yusuke Suzuki, Seiji Kakehata, Kimihiro Okubo, Hiroki Ikeda, Hiroshi Shiraishi and Kenji Izuhara
  • Journal Title: Allergology International Volume: 61 Pages: 589-595
  • Peer Reviewed
• [Presentation] 鼻疾患におけるペンドリンとペリオスチン (2014)
  • Author(s): 石田晃弘
  • Organizer: 杜 の 都 Allergic Rhinitis Seminar 2014
  • Place of Presentation: 仙台市 ホテルメトロポリタン仙台
  • Year and Date: 2014-10-19
  • Invited
• [Presentation] Investigation of Blood Serum Periostin Levels in Patients with Chronic Sinusitis (2014)
  • Author(s): Ishida A, Ohta N, Kakehata S, Izuhara K
  • Organizer: The 33rd International Symposium on Infection and Allergy of the Nose
  • Place of Presentation: Beurs van Berlage, Amsterdam, Netherland
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] Periostin levels in patients with chronic sinusitis. (2013)
  • Author(s): Ihida A, Ohta N, Kakehata, S
  • Organizer: The 16th Asian Research Symposium in Rhinology
  • Place of Presentation: Keio Plaza Hotel, tokyo
• [Presentation] Overexpression of Pendrin and Periostin in Nasal Disorders. (2013)
  • Author(s): Ihida A, Ohta N, Kakehata S, Izuhara K
  • Organizer: 7th International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis.
  • Place of Presentation: Kunibiki Messe, Matue, Shimane
• [Presentation] 慢性副鼻腔炎における血清中periostin量の検討 (2013)
  • Author(s): 石田晃弘 太田伸男 鈴木祐輔 倉上和也 欠畑誠治
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷市 倉敷芸文館
• [Presentation] Expression of Pendrin and Periostin in Nasal Disorders (2012)
  • Author(s): Akihiro Ishida, Nobuo Ota, Seiji Kakehata, Kenji Izuhara
  • Organizer: The 31st International Symposium on Infection and Allergy of the Nose
  • Place of Presentation: France Toulouse Centre de Congrès Pierre Baudis
• [Book] ペンドリン・ペリオスチンとアレルギー性鼻炎 (2013)
  • Author(s): 石田晃弘 太田伸男
  • Total Pages: 150
  • Publisher: 医薬ジャーナル社