| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We could not evaluate the CYP3A4 expression for hypopharyngeal cancer (HPC) treated with induction TPF regimen, because of technical problem. Therefore, we changed the contents of this study. Focal adhesion kinase (FAK) plays an important role in tumor metastasis. We evaluated the significance of FAK expression in surgically treated HPC patients. FAK expression status was retrospectively evaluated using immunohistochemistry. FAK-positive patients displayed significantly worse disease-specific survival than FAK-negative patients. Furthermore, FAK positivity significantly correlated with the number of metastatic lymph nodes, and FAK-positive patients displayed a higher incidence of distant metastases. In conclusion, upregulated FAK expression correlates with poor prognosis and tumor dissemination in surgically treated HPC patients.
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