Prediction of response to Docetaxel in head and neck squamous cell carcinoma
Project/Area Number |
24791750
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | The University of Tokyo |
Principal Investigator |
OMURA Go 東京大学, 医学部附属病院, 助教 (00601139)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 下咽頭癌 / 予後因子 / Focal Adhesion Kinase / 救済手術 / CAP3A4 / FAK / タキソテール / 感受性 |
Outline of Final Research Achievements |
We could not evaluate the CYP3A4 expression for hypopharyngeal cancer (HPC) treated with induction TPF regimen, because of technical problem. Therefore, we changed the contents of this study. Focal adhesion kinase (FAK) plays an important role in tumor metastasis. We evaluated the significance of FAK expression in surgically treated HPC patients. FAK expression status was retrospectively evaluated using immunohistochemistry. FAK-positive patients displayed significantly worse disease-specific survival than FAK-negative patients. Furthermore, FAK positivity significantly correlated with the number of metastatic lymph nodes, and FAK-positive patients displayed a higher incidence of distant metastases. In conclusion, upregulated FAK expression correlates with poor prognosis and tumor dissemination in surgically treated HPC patients.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing2015
Author(s)
Mizuo Ando, Yuki Saito, Teppei Morikawa, Go Omura, Kenya Kobayashi, Ken Akashi, Masafumi Yoshida, Yasuhiro Ebihara, Chisato Fujimoto, Masashi Fukayama, Tatsuya Yamasoba, Takahiro Asakage
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Journal Title
Head and Neck
Volume: 未定
Issue: 12
DOI
Related Report
Peer Reviewed
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[Journal Article] High Incidence of Null-Type Mutations of the TP53 Gene in Japanese Patients with Head and Neck Squamous Cell Carcinoma2014
Author(s)
Yasuhiro Ebihara, Miwako Iwai, Ken Akashi, Takeshi Ito, Go Omura, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba, Yoshinori Murakami
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Journal Title
Journal of Cancer Therapy
Volume: 5
Issue: 07
Pages: 664-671
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma2013
Author(s)
Yuki Saito MD1,*, Masafumi Yoshida MD1, Tetsuo Ushiku MD, PhD2, Go Omura MD1, Yasuhiro Ebihara MD1, Toshiyuki Shimono PhD3, Masashi Fukayama MD, PhD2, Tatsuya Yamasoba MD, PhD1 andTakahiro Asakage MD, PhD1
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Journal Title
Cancer
Volume: 119
Issue: 11
Pages: 2005-2011
DOI
Related Report
Peer Reviewed
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