The research of binaural function in the mouse auditory cortex

• Project/Area Number: 24791758
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Niigata University
• Principal Investigator: TAKAHASHI Kuniyuki 新潟大学, 医歯学系, 准教授 (40452057)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 大脳聴覚野 / マウス / イメージング / 両側 / 両耳聴

Outline of Final Research Achievements

It has been thought that there are not only functional areas in the unilateral auditory cortex but also functional differentiation and communication between bilateral hemispheres. We have improved our equipment to obtain the bilateral auditory cortex simultaneously and we have recorded the responses to various sounds in the mouse auditory cortex. And we have also research the relationship between bilateral auditory cortices with transcranial reversible photo-inactivation. As a result, we found the new areas which specifically respond to the frequency change direction of the frequency modulated sound, and the end of the sound in the mouse auditory cortex. We also found that the auditory responses were influenced by the inhibition of the opposite auditory cortex. We think that these results can contribute to further auditory cortex research.

Research Products

• [Presentation] The cortical area located dorsally to auditory cortex involved in sound-shape association memory in mice (2015)
  • Author(s): Tatsuya Yamagishi , Hiroaki Tsukano , Hironori Baba, Yuusuke Honma , Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki , Sugata Takahashi
  • Organizer: The 30th Politzer Society Meeting / the 1st World Congress of Otology
  • Place of Presentation: 朱鷺メッセ（新潟県、新潟市）
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] OFF responses produced by short-term depression of thalamic inputs to inhibitory neurons in the mouse auditory cortex (2015)
  • Author(s): Hironori Baba, Hiroaki Tsukano, Tatsuya Yamagishi, Yuusuke Honma, Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
  • Organizer: The 30th Politzer Society Meeting / the 1st World Congress of Otology
  • Place of Presentation: 朱鷺メッセ（新潟県、新潟市）
  • Year and Date: 2015-06-30
  • Int'l Joint Research
• [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluorescence imaging (2013)
  • Author(s): 高橋邦行、馬場洋徳、本間悠介、大島伸介、窪田和、高橋姿
  • Organizer: 2nd meeting of EA ORL-HNS and CE ORL-HNS
  • Place of Presentation: ニース（フランス）
• [Presentation] フラビン蛋白蛍光イメージングを用いた大脳聴覚野の研究
  • Author(s): 高橋邦行, 窪田和, 大島伸介, 本間悠介, 馬場洋徳, 髙橋姿, 塚野浩明, 菱田竜一, 澁木克栄
  • Organizer: 第１回基礎・臨床研究交流会
  • Place of Presentation: 新潟市
• [Presentation] マウス聴覚野OFF応答のイメージング解析
  • Author(s): 馬場洋徳, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 澁木克栄, 髙橋姿
  • Organizer: 第11回側頭骨疾患研究会
  • Place of Presentation: 東京都
• [Remarks] フラビン蛋白蛍光法を用いた聴覚野機能解析
  • URL: http://www.med.niigata-u.ac.jp/oto/about/research/