• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinical and pathological analysis of the sinonasal involvement in IgG4-related disease

Research Project

Project/Area Number 24791760
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

NAKANISHI Sayaka  金沢大学, 大学病院, 医員 (40532180)

Research Collaborator KANEDA Misako  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsIgG4関連疾患 / 嗅覚障害 / モデルマウス / IgG4関連疾患 / 嗅覚 / 慢性硬化性顎下腺炎 / EBウイルス
Outline of Final Research Achievements

IgG4-related disease (IgG4-RD) is a newly recognized systemic disease. However, little is known about the sinonasal manifestations. This study examined the prevalence of and etiology of olfactory impairment in patients with IgG4-RD by analyzing its clinical features. We also examined the olfactory function of IgG4-RD model mice to investigate the mechanisms underlying olfactory dysfunction. About half of the patients with IgG4-RD presented with moderate to severe olfactory dysfunction. Olfactory dysfunction is a potentially important manifestation of this disease. We examined the IgG4-RD model mice to investigate the mechanisms underlying olfactory dysfunction. Olfactory behavioral testing revealed that the model mice showed mild to moderate olfactory dysfunction. Histological analysis showed that there was no typical pathological finding of IgG4-RD in the olfactory epithelium. The function of newly differentiated and mature olfactory nerve cells were both impaired.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2013 2012

All Presentation (3 results)

  • [Presentation] IgG4 関連疾患における嗅覚障害の検討2015

    • Author(s)
      兼田美紗子、中西清香、尾崎ふみ、近藤悟、吉崎智一
    • Organizer
      第116回日本耳鼻咽喉科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-05-20 – 2015-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性硬化性唾液腺炎とIgG4関連疾患の病態像に 関する考察~EBVとの関連について~2013

    • Author(s)
      中西清香
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館(岡山県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Ig4関連疾患における嗅覚障害の検討2012

    • Author(s)
      中西清香
    • Organizer
      第51回日本鼻科学会総会
    • Place of Presentation
      千葉県幕張メッセ(千葉県)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi