Analysis of sensitization and onset of allergic rhinitis
| Project/Area Number |
24791761
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アレルギー性鼻炎 / Th2サイトカイン / コラーゲン産生 / 好酸球浸潤 / マイクロアレイ |
|---|
| Research Abstract |
We measured Japanese cedar (JC) specific IgE in serum about 3453 subjects and found that 57.5% of these subjects possess JC-specific IgE. Among them who have high-JC-specific IgE, 72.2% of these subjects show allergic rhinitis (AR) related symptoms during JC pollen, while the other subjects had not experienced any AR related symptoms. These subjects are only sensitized subjects. We studied the levels of chemokines related to AR among non-atopic subjects, sensitized subjects, and patients with seasonal allergic rhinitis by JC pollen in order to predict onset of AR. We also performed gene expression analysis and found that Cystatin SN (CST1) was a candidate gene that affect sensitization and onset of AR.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T
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Journal Title
J Allergy Clin Immunol
Volume: (in press)
Issue: 1
Pages: 184-194
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector2012
Author(s)
Ono M, Hamada Y, Horiuchi Y, Matsuo-Takasaki M, Imoto Y, Satomi K, Arinami T, Hasegawa M, Fujioka T, Nakamura Y, Noguchi E
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: e42855-e42855
DOI
Related Report
Peer Reviewed
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[Presentation] アレルギー性鼻炎のバイオマーカー2013
Author(s)
意元義政, 坂下雅文, 徳永貴広, 山本英之, 加藤雄士, 山田武千代, 藤枝重治
Organizer
第25回日本アレルギー学会春季学術大会
Place of Presentation
横浜
Year and Date
2013-05-11
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