The vestibular function of hereditary hearing loss patients
| Project/Area Number |
24791766
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
TSUKADA Keita 信州大学, 学術系研究院医学系(医学部附属病院), 助教 (90419375)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 平衡 / 遺伝子 / 前庭機能 / 難聴 / 遺伝性難聴 / 温度眼振検査 / ＶＥＭＰ / 平衡機能 / 前庭 |
|---|
| Outline of Final Research Achievements |
Recently, by the developement of mutation screening, 30-35% of congenital hearing loss patients could be diagnosed as genetic cause. The detailed audiologic features, including genotype-phenotype correlations and progression in patients with genetic mutations, have been well studied. However, there have been only a few reports on vestibular function of hereditary hearing loss patients despite abundant gene and protein expression of causative genes in the vestibular end organs. We summarize the results of our comprehensive study on vestibular function in patients with hearing loss caused by GJB2, SLC26A4, CDH23 mutation. In this study, we found the high incidence of saccular defects in patients with GJB2 mutations and semicircular canal dysfunction in patients with SLC26A4 mutations. This result will also facilitate the clinical application of genetic counseling for these patients and their families.
|
Report
(4 results)
Research Products
(9 results)
-
-
-
-
[Journal Article] Gene Expression Profiles of the Cochlea and Vestibular Endorgans: Localization and Function of Genes Causing Deafness.2015
Author(s)
Nishio SY, Hattori M, Moteki H, Tsukada K, Miyagawa M, Naito T, Yoshimura H, Iwasa YI, Mori K, Shima Y, Sakuma N, Usami SI.
-
Journal Title
Ann Otol Rhinol Laryngol
Volume: 124
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Hearing preservation and clinical outcome of 32 consecutive electric acoustic stimulation (EAS) surgeries.2014
Author(s)
Usami S, Moteki H, Tsukada K, Miyagawa M, Nishio SY, Takumi Y, Iwasaki S, Kumakawa K, Naito Y, Takahashi H, Kanda Y, Tono T.
-
Journal Title
Acta Otolaryngol.
Volume: 134
Pages: 717-727
Related Report
Peer Reviewed
-
-
-
