| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The 5-hydroxytryptamine type3(5-HT3) receptor is a ligand-gated ion channel and a member of the Cys-loop family of receptors. Previous studies have shown 5-HT3 receptor expression in various neural cells of the central and peripheral nervous systems. However, no study has yet determined its localization and function in the peripheral vestibular nervous system. In the present study, we reveal mRNA expression of both 5-HT3 receptor in the mouse vestibular ganglion by in situ hybridization. Moreover, we performed Ca2+ imaging to determine whether function al 5-HT3 receptors are present in the mouse vestibular ganglion. These results indicate that vestibular ganglion cells express functional 5-HT3 receptor channels and might play a modulatory role in the peripheral vestibular nervous system.
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