Base study for the radical treatment of the cedar pollinosis by the identification of the Tr1 instruction cedar pollen epitope
| Project/Area Number |
24791780
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
NODA Yohei 岡山大学, 大学病院, 助教 (00587404)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | スギ花粉症 / 健常人 / IL-10 / 制御性細胞 / ペプチド / 免疫寛容 / 制御性Ｔ細胞 / LAG-3 / 制御性T細胞 |
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| Research Abstract |
We sought to determine the cellular responses to Cry j 1, the major allergen of Japanese cedar pollen, in healthy Japanese. Peripheral blood mononuclear cells produced a substantial amount of IL-10 in response to Cry j 1. We synthesized 45 overlapping peptide with 15 amino acids from N-terminal of Cry j 1. However, we could not find a particular peptide in which PBMCs from healthy subjects produced IL-10. In addition, we found that LAG-1 and CD201 positive population in CD4 positive cells were increased in response to Cry j 1, suggesting that Tr1 is induced in healthy subject following the exposure to Japanese cedar pollen
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Report
(3 results)
Research Products
(10 results)
