Leukotriene receptor variation and it's role in intractable eoshinophilic rhino sinusitis.

Research Project

Project/Area Number	24791791
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Kagoshima University
Principal Investigator	OHORI Junichiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (90507162)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	好酸球 / 上皮 / VEGF / ロイコトリエン
Research Abstract	In order to investigate the role of cysteinyl leukotriene receptor 2 (CysLT2R) in eoshinophilic rhino sinusitis, the production of VEGF from Epithelial cells, the expression of CysLT2R on eosinophil, and the interaction between epithelial cells and eosinophil were examined. It was observed that the autocrine effect in VEGF production on the epithelial cell of nasal mucosa. The expression of CysLT2R was higher than that of CysLT1R on eosinophil. Further, the accentuation of VEGF production was observed in coculture of epithelial cells and eosinophils. These data suggested that CysLT2R and VEGF were one of the couse regarding the refractory pathology of eosinophilic rhino sinusitis.

Report

(3 results)