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The Signaling Pathway of Lysophosphatidic Acid in Head and Neck Squamous Cell Carcinoma:The Role of Non-EDG Family Receptors

Research Project

Project/Area Number 24791792
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

MATAYOSHI Sen  琉球大学, 医学部附属病院, 助教 (60448587)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsリゾフォスファチジン酸 / LPA / 頭頸部癌 / Gタンパク共役受容体 / LPA4 / Gタンパク共役型受容体
Outline of Final Research Achievements

Lysophosphatidic acids (LPAs) have been implicated in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). LPA receptors belong to endothelial differentiation gene (Edg) family (LPA1-3) and phylogenetically distant non-Edg family (LPA4- 6). In the present study, we investigated the effect of ectopic expression of LPA4 in SQ-20B, a HNSCC cell line, which expressed trivial level of endogenous LPA4. LPA stimulated proliferation of SQ-20B cells. Infection with doxycycline-regulatable adenovirus vector expressing green fluorescent protein-tagged LPA4 (AdvLPA4G) abolished LPA-stimulated proliferation in SQ-20B cells with the accumulation of G2/M-phasic cells. In the presence of Ki16425 or Rac1 inhibitor, ectopic LPA4-expressing SQ-20B cells showed further down-regulation of the proliferation. LPA induced cell motility was suppressed by ectopic LPA4 expression. Our data suggest that LPA4 signaling potentially modulates malignant behaviors of SQ-20B cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells2013

    • Author(s)
      Matayoshi S, Chiba S, Lin Y, Arakaki K, Matsumoto H, Nakanishi T, Suzuki M, Kato S.
    • Journal Title

      Int J Oncol

      Volume: 42 Issue: 5 Pages: 1560-1568

    • DOI

      10.3892/ijo.2013.1849

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in Laryngeal carcinoma cells2014

    • Author(s)
      Sen Matayoshi
    • Organizer
      the American Academy of Otolaryngology-Head and Neck Surgery Foundation
    • Place of Presentation
      Orland, USA
    • Year and Date
      2014-09-21 – 2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 喉頭扁平上皮癌細胞におけるリゾフォスファチジン酸受容体LPA4遺伝子導入の効果2013

    • Author(s)
      又吉宣
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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