Analysis of invasion and metastasis system in pharyngeal carcinoma by epitherial cell polar factor and hippo signal pathway

• Project/Area Number: 24791795
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: KONDO Atsushi 札幌医科大学, 医学部, 講師 (40457718)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 咽頭癌 / 細胞極性 / タイト結合 / 接着分子

Research Abstract

Recently, it is reported that JAM-A is closely associated with invasion and metastasis of cancers such as breast cancer, esophageal cancer. However little is known about the role of JAM-A in invasion and metastasis of head and neck squamous cell carcinoma. Head and neck squamous cell carcinoma tissues obtained by surgery from patients with head and neck carcinoma.To investigate expression and distribution of JAM-A, we performed real-time PCR, immunofluorescence staining by using frozen sections and immunohistochemistry by using paraffin sections. JAM-A was highly expressed in head and neck squamous cell carcinoma

Research Products

• [Journal Article] A Case of Tonsillar Metastasis from Large-cell Neuroendocrine Carcinoma of the Lung (2013)
  • Author(s): 計良宗, 今井良吉, 近藤敦, 黒瀬誠, 氷見徹夫
  • Journal Title: Practica Oto-Rhino-Laryngologica Volume: 106 Issue: 1 Pages: 41-45
  • DOI: 10.5631/jibirin.106.41
  • NAID: 10031141236
  • ISSN: 0032-6313, 1884-4545
  • Peer Reviewed
• [Journal Article] 気管切開術を要した甲状舌管嚢胞の1 例 (2013)
  • Author(s): 山本圭佑, 関伸彦, 近藤敦, 氷見徹夫, 他
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 85 Pages: 633-637
  • URL: http://top.islib.jp/bcs/ct/medicalfinder/fixedViewPdf.do?isid=1411102579
  • Peer Reviewed
• [Journal Article] Phase I study of oral S-1 and concurrent radiotherapy in patients with head and neck cancer. (2013)
  • Author(s): Nakata K, Sakata K, Someya M, Miura K, Hayashi J, Hori M, Takagi M, Himi T, Kondo A, Hareyama M.
  • Journal Title: J Radiat Res Volume: 54（4） Issue: 4 Pages: 679-683
  • DOI: 10.1093/jrr/rrs133
  • Peer Reviewed
• [Journal Article] 肺大細胞神経内分泌癌扁桃転移例 (2013)
  • Author(s): 計良宗、今井良吉、近藤敦、黒瀬誠、氷見徹夫
  • Journal Title: 耳鼻臨床 Volume: 106 Pages: 41-45
  • NAID: 10031141236
  • Peer Reviewed
• [Journal Article] 気管切開術を要した甲状舌管嚢胞の1例 (2013)
  • Author(s): 山本 圭佑, 関 伸彦, 白崎 英明, 近藤 敦, 長屋 朋典, 宮田 遼, 氷見 徹夫
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 85 Pages: 633-7
  • Peer Reviewed
• [Journal Article] Phase I study of oral S-1 and concurrent radiotherapy in patients with head and neck cancer. (2013)
  • Author(s): Nakata K, Sakata KI, Someya M, Miura K, Hayashi J, Hori M, Takagi M, Himi T, Kondo A, Hareyama M.
  • Journal Title: Radiat Res Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells (2012)
  • Author(s): Fuchimoto J, Kojima T, Himi T(全12名2, 11番)
  • Journal Title: Am J Rhinol Allergy Volume: 26(6) Issue: 6 Pages: 433-8
  • DOI: 10.2500/ajra.2012.26.3814
  • Peer Reviewed
• [Journal Article] Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy (2012)
  • Author(s): Hayashi J, Sakata KI, Someya M, Matsumoto Y, Satoh M, Nakata K, Hori M, Takagi M, Kondoh A, Himi T, Hareyama M
  • Journal Title: Oncol Lett Volume: 4 Pages: 151-155
  • URL: http://www.spandidos-publications.com/10.3892/ol.2012.674
  • Peer Reviewed
• [Journal Article] Malignant melanoma of the head and neck : A multi-institutional retrospective analysis of cases in Northern Japan (2012)
  • Author(s): Shiga K, Ogawa T, Kobayashi T, Ueda S, Kondo A, Nanba A, Kuwashima S, Asada Y, Suzuki S, Nagahashi T, Takahashi M, Suzuki M, Ishida A, Watanabe K, Harabuchi Y, Himi T, Shinkawa H, Sato H, Saijyo S, Fukuda S, Tanaka K, Ishikawa K, Omori K, Aoyagi M, Hashimoto S
  • Journal Title: Head Neck Volume: (in press) Issue: 11 Pages: 1537-1541
  • DOI: 10.1002/hed.21984
  • Peer Reviewed
• [Journal Article] 原発性気管腺癌の一例 (2012)
  • Author(s): 山下恵司, 近藤敦, 他
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 84 Pages: 663-667
  • URL: http://top.islib.jp/bcs/ct/medicalfinder/fixedViewPdf.do?isid=1411102257
  • Peer Reviewed
• [Journal Article] Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy. (2012)
  • Author(s): Hayashi J, Sakata KI, Someya M, Matsumoto Y, Satoh M, Nakata K, Hori M, Takagi M, Kondoh A, Himi T, Hareyama M
  • Journal Title: Oncol Lett Volume: 4(1) Pages: 151-155
  • Peer Reviewed
• [Journal Article] 原発性気管腺癌の一例 (2012)
  • Author(s): 山下恵司
  • Journal Title: 耳鼻咽喉科・頭頸部外科 Volume: 84（9） Pages: 663-667
• [Presentation] 下咽頭進行癌における手術症例の検討 (2014)
  • Author(s): 近藤敦, 黒瀬誠, 氷見徹夫
  • Organizer: 日本頭頸部外科学会
  • Place of Presentation: 高松
  • Year and Date: 2014-01-30
• [Presentation] 当科で治療した副耳下腺腫瘍の検討 (2013)
  • Author(s): 角木拓也, 近藤敦, 氷見徹夫, 他
  • Organizer: 耳鼻咽喉科臨床学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-07-11
• [Presentation] G-CSF産生下咽頭癌の1例 (2013)
  • Author(s): 實川純人, 近藤敦, 氷見徹夫, 他
  • Organizer: 日本口腔咽頭科学会
  • Place of Presentation: 名古屋
• [Presentation] 当科における下咽頭癌の臨床的検討 (2013)
  • Author(s): 近藤敦, 黒瀬誠, 氷見徹夫
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 当科における原発不明転移性頸部癌の検討 (2013)
  • Author(s): 小幡和史, 近藤敦, 黒瀬誠, 氷見徹夫
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 頭頸部扁平上皮癌浸潤, 転移におけるS100A7, タイト結合分子JAM-A 意義 (2013)
  • Author(s): 黒瀬誠, 近藤敦, 氷見徹夫
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Negative regulator S100A7 in tumor progression of head and neck squamous cell carcinoma (2013)
  • Author(s): Kazuaki Nomura, Takashi Kojima, Atsushi Kondo, Tetsuo Himi, et al
  • Organizer: 3rd congress Asian Society of Head and Neck Oncology
  • Place of Presentation: フィリピン
• [Presentation] 頭頸部扁平上皮癌浸潤、転移におけるS100A7,タイト結合分子JAM-Aの意義 (2013)
  • Author(s): 黒瀬誠、近藤敦、氷見徹夫
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] Negative regulator S100A7 in tumor progression of head and neck squamous cell carcinoma (2013)
  • Author(s): Kazuaki Nomura, Takashi Kojima, Atsushi Kondo,Tetsuo Himi,et al
  • Organizer: 3rd congress Asian Society of Head and Neck Oncology
  • Place of Presentation: フィリピン セブ島
• [Presentation] 頭頸部扁平上皮癌におけるタイト結合分子, 転写因子の発現 (2012)
  • Author(s): 黒瀬誠, 近藤敦, 氷見徹夫, 他
  • Organizer: 日本気管食食道学会
  • Place of Presentation: 東京
• [Presentation] 小児の副耳下腺より発生した腺房細胞癌症例 (2012)
  • Author(s): 近藤敦, 氷見徹夫, 他
  • Organizer: 日本口腔咽頭科学会
  • Place of Presentation: 熊本
• [Presentation] 大きな嚢胞形成を伴った耳下腺adenomatous ductal proliferation の1 例 (2012)
  • Author(s): 関伸彦, 近藤敦, 他
  • Organizer: 日本口腔咽頭科学会
  • Place of Presentation: 熊本
• [Presentation] 気管切開を要した甲状舌管嚢胞の1 例 (2012)
  • Author(s): 山本圭佑, 近藤敦, 氷見徹夫, 他
  • Organizer: 耳鼻咽喉科臨床学会
  • Place of Presentation: 東京
• [Presentation] Elastase によるヒト鼻粘膜上皮バリア機能への影響 (2012)
  • Author(s): 野村一顕, 他
  • Organizer: 日本再生・炎症学会
  • Place of Presentation: 福岡
• [Presentation] Elastaseによるヒト鼻粘膜上皮バリア機能への影響 (2012)
  • Author(s): 野村一顕 他
  • Organizer: 第33回日本再生・炎症学会
  • Place of Presentation: 福岡市
• [Presentation] Elastaseによるヒト鼻粘膜上皮バリア機能への影響 (2012)
  • Author(s): 野村一顕 他
  • Organizer: 第51回日本鼻科学会
  • Place of Presentation: 千葉市
• [Presentation] 頭頸部扁平上皮癌におけるタイト結合分子，転写因子の発現 (2012)
  • Author(s): 黒瀬誠，近藤敦 他
  • Organizer: 第64回日本気管食食道学会
  • Place of Presentation: 東京
• [Book] 病態・疾患別 がん性痛の治療 (2013)
  • Author(s): 近藤敦, 渡邊昭彦
  • Publisher: 文光堂
• [Book] 病態・疾患別 がん性痛の治療 (2013)
  • Author(s): 近藤敦，渡邊昭彦
  • Total Pages: 8
  • Publisher: 文光堂
• [Book] 上気道炎症における鼻粘膜の役割 氷見徹夫編 (2012)
  • Author(s): 黒瀬誠，近藤敦
  • Total Pages: 433
  • Publisher: アイワード札幌