| Project/Area Number |
24791796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TANI Akiko 福島県立医科大学, 医学部, 助手 (30554430)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Yasuhiro 福島県立医科大学, 医学部, 講師 (70363760)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 気管粘膜再建 / ビトリゲル / 線維芽細胞増殖因子 / コラーゲンスポンジ / 移植再生医療 |
|---|
| Research Abstract |
In this study, the effectiveness of our scaffold with application of basic fibroblast growth factor(b-fgf) was investigated. Three types of scaffold were made: no b-FGF, 10ng b-FGF, and 100ng b-FGF. At 7,14 and 28 days after implantation in rats, the trachea were removed and histologically evaluated. The regeneration of mucosal epithelium and the subepithelial layer was evaluated.
Our technique for tracheal reconstruction affords a feasible approach for accelerating the regeneration of the intraluminal surface and subepithelial layer of tracheal tissue.
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