| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Laryngeal symptom such as cough and hoarseness show difference between day and night. Bradykinin is known both as an inflammatory mediator and pain producing substance. It is also known as bradykinin mediate the dry cough in the patients on ACE inhibitor. Bradykinin receptor has two subtypes, B1 and B2 receptors. The distribution of Bradykinin receptors in the larynx has not been reported so far. We conducted a study for revealing the distribution of Bradykinin receptors in the larynx and the circadian change of them. Both B1 and B2 receptor are distributed in the superficial layer of the ciliated epithelium. Expression was very weak in the squamous epithelium of the vocal folds. Both B1 and B2 was distributed also in the sensory system of the larynx especially in the nodose ganglion and submucosal sensory fibers. As far as we studied, circadian change of Bradykinin expression was not observed in the rat larynx.
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