A study of head and neck cancer treatment targeting signaling pathway to induce the cancer stem cells and the Epithelial-mesenchymal transition

• Project/Area Number: 24791806
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: SATO Yoichiro 慶應義塾大学, 医学部, 助教 (40624440)
• Research Collaborator: IMANISHI Yorihisa 慶應義塾大学, 医学部, 講師 (80255538) ; WATANABE Yoshihiro 慶應義塾大学, 医学部, 助教 (30445374)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 頭頸部癌 / 上皮間葉移行 / 癌幹細胞 / 癌転移 / 分子標的治療 / 頭頸部扁平上皮癌（HNSCC） / EMT（上皮-間葉移行）

Research Abstract

Oct3/4 and Nanog expression putative cancer stem cells with enhanced cell migration and invasion, and then was thought to induce EMT, experiencing the metastasis in head and neck squamous cell carcinoma. That could lead to new treatment for targeting cancer stem cells, such as oct3/4, Nanog recurrence and metastasis inhibition was suggested.

Research Products

• [Presentation] 頭頸部扁平上皮癌における癌幹細胞様細胞マーカーの発現とその臨床的意義に関する検討 (2013)
  • Author(s): 羽生昇, 今西順久, 坂本耕二, 大塚邦憲, 佐藤陽一郎, 渡部佳弘, 小川郁, 徳丸裕, 藤井正人
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-26
• [Presentation] 頭頸部扁平上皮癌におけるがん幹細胞様細胞の存在とmarker の発現に関する検討 (2013)
  • Author(s): 羽生昇, 今西順久, 徳丸裕, 冨田俊樹, 坂本耕二, 重冨征爾, 佐藤陽一郎, 渡部佳弘, 藤井正人, 小川郁
  • Organizer: 第114回日本耳鼻咽喉科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-05-18
• [Presentation] 鼻中隔粘膜弁114例の検討 (2013)
  • Author(s): 佐藤陽一郎
  • Organizer: 日本頭頸部外科学会
  • Place of Presentation: 城山観光ホテル（鹿児島県）
• [Presentation] Expression of stem cell markers Oct3/4 and Nanog and its clinical significance in oral tongue SCC (2012)
  • Author(s): Noboru Habu, Yorihisa Imanishi, Koji Sakamoto, Yutaka Tokumaru, Masayuki Shimoda, Kaori Kameyama, Yoichiro Sato, Seiji Shigetomi, Toshiki Tomita, Kaoru Ogawa, Masato Fujii
  • Organizer: The 8th International Conference on Head and Neck Cancer at MetroToronto Convention
  • Place of Presentation: Centre/ Toronto
  • Year and Date: 2012-07-24
• [Presentation] 副咽頭間隙に発生した血管内皮細胞由来と考えられるspindle cell sarcomaの一例 (2012)
  • Author(s): 佐藤陽一郎
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 島根県民会館