| Project/Area Number |
24791807
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
KASAI Misato 順天堂大学, 医学部, 助教 (70549279)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 先天性難聴 / 遺伝子変異 / 平衡機能障害 / コネキシン26遺伝子 / 運動機能 / 平衡失調遺伝子 / 難聴遺伝子 / 前庭機能 / GJB2 / 遺伝性難聴 |
|---|
| Research Abstract |
It is well known that the fundamental cause responsible for congenital deafness is brought about by the gene mutations. Furthermore, deafened subjects also suffer from disequilibrium. My previous study suggested that the gene of connexin26 (GJB2), the most prevalent form of deafness genes, influenced vestibular system as well auditory function. In the present study, I aimed to resolve the underlying mechanism pf the vestibular function on the basis of objective evaluation of both excise and vestibular function in addition to the analysis of multiple deafness genes, which may be defined as the imbalance gene.
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