| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We analyzed the role of Th9 cells in upper and lower airway inflammation using adoptive transfer models. Both Th2 cells and Th9 cells induce eosinophil accumulation in the lung and airway hyperresponsiveness (AHR) to the inhaled methacholine in bronchial asthma model, and also induce eosinophil accumulation in the nasal cavity and sneezing responses in alelrgic rhinitis model. Th2-induced AHR was abolished by eosinophil deficiency. In contrast, Th9-induced AHR is hardly affected by eosinophil deficiency.
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