Development of vaccination for head and neck cancer utilizing antigen presentation by autophagy
| Project/Area Number |
24791820
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍免疫 / 頭頸部癌 / autophagy / LC3 / TIL / HLA / 免疫組織化学 / オートファジー / 頭頸部扁平上皮癌 / 抗原提示 / 頭頸部癌（頭頸部扁平上皮癌） / 腫瘍免疫（がんワクチン） / 抗原提示（HLA分子・HLA class I） / オートファジーautophagy（自己消化） |
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| Outline of Final Research Achievements |
Autophagy is an endogenous process that degrades bulk proteins and organelles to maintain energy homeostasis under cellular stress and nutrient starvation. To explore the association between autophagy and anti-tumor immune responses, we investigated the expression of 3 autophagy-related proteins, HLA molecules and infiltration of 3 kinds of immune cells in 74 patients with oral squamous cell carcinoma in relation to various clinicopathological parameters.
Interestingly, autophagy was significantly associated with lymphocyte infiltrations and HLA expressions. Meanwhile, several unfavorable clinicopathological parameters including short overall survival significantly correlates with autophagy. Autophagy is likely to actively mobilize immune cells toward cancer bed and increase tumor antigenicity, while autophagy also relates to malignant potentials and unfavorable prognosis. This results was published in Cancer Science, in addition to other 4 publications.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.2014
Author(s)
Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Head Neck.
Volume: in press
Issue: 11
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.2014
Author(s)
Toyoda M, Kaira K, Ohshima Y, Ishioka NS, Shino M, Sakakura K, Takayasu Y, Takahashi K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Br J Cancer.
Volume: 110
Issue: 10
Pages: 2506-13
DOI
Related Report
Peer Reviewed / Open Access
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