| Project/Area Number |
24791822
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KASE Satoru 北海道大学, 医学(系)研究科(研究院), 客員研究員 (60374394)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | alpha-crystallin / VEGF / 新生血管 / alphaB-crystallin / 血管新生 |
|---|
| Research Abstract |
It was hard to collect human choroidal neovascular membranes. Instead, we have isolated human epiretinal proliferative membranes in patients with diabetic retinopathy during vitrectomy. Using these samples, we analyzed expression of molecular chaperone alphaB-crystallin, a VEGF chaperone, and its phosphorylations. Indeed, alphaB-crystallin was expressed in the neovessels of the epiretinal membrane. Moreover, co-locatiozation with alphaB-crystallin and VEGF, as well as association between alphaB-crystallin serine phosphorylation and VEGF were confirmed.
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