• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of receptor-associated prorenin system in the retina

Research Project

Project/Area Number 24791823
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

KANDA Atsuhiro  北海道大学, 医学(系)研究科(研究院), 特任講師 (80342707)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords(プロ)レニン受容体 / プロレニン / レニン・アンジオテンシン 系 / 血管新生 / 網膜疾患 / レニン・アンジオテンシン系 / (プロ)レニン受容体
Outline of Final Research Achievements

(Pro)renin receptor is known to regulate tissue RAS and RAPS, and involved in the pathogenesis of several ocular disorders. However, its physiological functions remain unclear. The goal of this study is to gain additional insights into the pathological and biological function of (pro)renin receptor using clinical samples and animal models.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (44 results)

All 2015 2014 2013 2012

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 b-subunit.2015

    • Author(s)
      Kanda A, Noda K, Ishida S.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 15 Pages: 9690-9700

    • DOI

      10.1074/jbc.m114.626713

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of the receptor-associated prorenin system in the pathogenesis of human conjunctival lymphoma.2014

    • Author(s)
      Ishizuka ET, Kanda A, Kase S, Noda K, Ishida S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56 Issue: 1 Pages: 74-80

    • DOI

      10.1167/iovs.14-15743

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genistein attenuates choroidal neovascularization2014

    • Author(s)
      Kinoshita S, Noda K, Tagawa Y, Inafuku S, Dong Y, Fukuhara J, Dong Z, Ando R, Kanda A, Ishida S
    • Journal Title

      J Nutr Biochem

      Volume: 25 Issue: 11 Pages: 1177-1182

    • DOI

      10.1016/j.jnutbio.2014.06.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comparison of N-glycan profiles in human plasma and vitreous fluid.2014

    • Author(s)
      Inafuku S, Noda K, Amano M, Ohashi, Yoshizawa C, Saito W, Kanda A, Nishimura S, Ishida S.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 252 Issue: 8 Pages: 1235-1243

    • DOI

      10.1007/s00417-014-2671-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde derived-advanced glycation end product formation.2014

    • Author(s)
      Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S
    • Journal Title

      J Leukoc Biol

      Volume: 96 Issue: 6 Pages: 1077-1085

    • DOI

      10.1189/jlb.3a0513-288rrr

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice.2014

    • Author(s)
      Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 7 Pages: 4682-4690

    • DOI

      10.1167/iovs.13-13272

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aqueous humor levels of placental growth factor in diabetic retinopathy2014

    • Author(s)
      Ando R, Noda K, Namba S, Saito W, Kanda A, Ishida S
    • Journal Title

      Acta Ophthalmol

      Volume: 92 Issue: 3 Pages: 245-246

    • DOI

      10.1111/aos.12251

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase.2014

    • Author(s)
      Saito M, Saito W, Kanda A, Ohguro H, Ishida S.
    • Journal Title

      BMC Ophthalmol.

      Volume: 14 Issue: 1 Pages: 5-5

    • DOI

      10.1186/1471-2415-14-5

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor in human ocular adnexal lymphoma.2014

    • Author(s)
      Kinoshita S, Kase S, Ando R, Dong Z, Fukuhara J, Dong Y, Takashina S, Noda K, Noda M, Kanda A, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 6 Pages: 3461-3467

    • DOI

      10.1167/iovs.13-13510

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 増殖糖尿病網膜症の病態形成における(プロ)レニン受容体.2014

    • Author(s)
      神田敦宏
    • Journal Title

      日本眼科学会雑誌

      Volume: 118 Pages: 916-926

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病網膜症とRAS2014

    • Author(s)
      神田敦宏、石田 晋
    • Journal Title

      Angiotensin Research

      Volume: 11 Pages: 190-193

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor in eyes with Coats disease.2013

    • Author(s)
      Kase S, Rao NA, Yoshikawa H, Fukuhara J, Noda K, Kanda A, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54 Issue: 1 Pages: 57-62

    • DOI

      10.1167/iovs.12-10613

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor.2013

    • Author(s)
      Fukuhara J, Noda K, Murata M, Namba S, Kinoshita S, Dong Z, Ando R, Lennikov A, Kanda A, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Issue: 1 Pages: 274-279

    • DOI

      10.1167/iovs.12-10512

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy.2013

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Journal Title

      Br J Ophthalmol.

      Volume: 97 Issue: 5 Pages: 666-668

    • DOI

      10.1136/bjophthalmol-2012-302680

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor C in human pterygium.2013

    • Author(s)
      Fukuhara J, Kase S, Ohashi T, Ando R, Dong Z, Noda K, Ohguchi T, Kanda A, Ishida S.
    • Journal Title

      Histochem Cell Biol

      Volume: 139 Issue: 2 Pages: 381-389

    • DOI

      10.1007/s00418-012-1019-z

    • NAID

      120005228265

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitreous renin-angiotensin system is mediated by soluble (pro)renin receptor in diabetic retinopathy: new implication of receptor-associated prorenin system.2013

    • Author(s)
      Kanda A, Ishida S.
    • Journal Title

      Twn J Ophthalmol.

      Volume: 3 Pages: 51-53

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Atp6ap2/(Pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.2013

    • Author(s)
      Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A & Ishida S
    • Journal Title

      J Neurosci.

      Volume: 33 Issue: 49 Pages: 19341-19351

    • DOI

      10.1523/jneurosci.1362-13.2013

    • NAID

      120005438252

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.2013

    • Author(s)
      Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 536-543

    • NAID

      120005372289

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of alphaB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma.2013

    • Author(s)
      Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Dong Y, Takashina S, Kanda A, Noda M, Noda K, Ishida S.
    • Journal Title

      Anticancer Res.

      Volume: 33 Pages: 3745-3751

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy2013

    • Author(s)
      Yaguchi H, Yabe I, Takahashi H, Okumura F, Takeuchi A, Horiuchi, K, Kan T, Kanda, A, Saito W, Matsumoto M, Nakayama KI, Hatakeyama S and Sasaki H
    • Journal Title

      J. Neurol.

      Volume: 261 Issue: 1 Pages: 224-226

    • DOI

      10.1007/s00415-013-7134-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye.2012

    • Author(s)
      Kanda A, Noda K, Oike Y, Ishida S.
    • Journal Title

      Lab Invest.

      Volume: 92 Pages: 1553-1563

    • NAID

      120005228682

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy.2012

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Journal Title

      Diabetologia.

      Volume: 55 Pages: 3104-3113

    • NAID

      40019966951

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Receptor-associated prorenin system in the pathogenesis of retinal diseases.2012

    • Author(s)
      Satofuka S, Kanda A, Ishida S.
    • Journal Title

      Front Biosci.

      Volume: 4 Pages: 1449-1460

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of (pro)renin receptor/Atp6ap2-binding proteins in the retina of adult mice.2015

    • Author(s)
      Kanda A, Noda K, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Florida, USA
    • Year and Date
      2015-05-04 – 2015-05-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] (プロ)レニン受容体と糖代謝2015

    • Author(s)
      神田敦宏
    • Organizer
      第7回(プロ)レニン受容体フォーラム
    • Place of Presentation
      熊本大学(熊本県、熊本市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the E1 β subunit of pyruvate dehydrogenase complex.2015

    • Author(s)
      Kanda A, Noda K, Ishida S.
    • Organizer
      Asia-ARVO 2015
    • Place of Presentation
      Pacifico Yokohama(Kanagawa, Yokohama)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mice.2015

    • Author(s)
      Kanda A.
    • Organizer
      Asia-ARVO 2015
    • Place of Presentation
      Pacifico Yokohama(Kanagawa, Yokohama)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mouse.2015

    • Author(s)
      Kanda A.
    • Organizer
      2015 Meeting with Hokkaido University & Chang Gung Memorial Hospitals
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-01-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mouse.2014

    • Author(s)
      Kanda A
    • Organizer
      9th Japan-Korea International Symposium in Ophthalmology
    • Place of Presentation
      Hokkaido University(Hokkaido, Sapporo)
    • Year and Date
      2014-12-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 網膜におけるレニン・アンジオテンシン系2014

    • Author(s)
      神田敦宏
    • Organizer
      第1回眼科基礎研究の会
    • Place of Presentation
      ホテル三浦華園(北海道、滝川市)
    • Year and Date
      2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.2014

    • Author(s)
      Kanda A, Yuki K, Furukawa T, Ichihara A, Ishida S.
    • Organizer
      World Ophthalmology Congress 2014 Tokyo
    • Place of Presentation
      Tokyo International Forum(Tokyo, Chiyoda)
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy2014

    • Author(s)
      神田敦宏
    • Organizer
      第118回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional analysis of (pro)renin receptor in mouse retinal development2013

    • Author(s)
      Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S.
    • Organizer
      The 11th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional analysis of (pro)renin receptor in mouse retinal development2013

    • Author(s)
      Kanda A, Noda K, Yuki K, Ozawa Y, Fukuhara T, Ichihara A, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Washington State Convention Center (Seattle, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス網膜発生における(プロ)レニン受容体の生理的機能解析2013

    • Author(s)
      神田敦宏、野田航介、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋
    • Organizer
      第117回 日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy2012

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Organizer
      10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido University(Sapporo, Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] ARMS2 Association with the Mitochondrial Outer Membrane is Reduced in RPE Cells Exposed to Oxidative Stress and in AMD2012

    • Author(s)
      Boulton M, Qi X, Kanda A, Nellissery J, Mitter S, Grant M, Swaroop A.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Broward County convention Center( 米国)
    • Related Report
      2012 Research-status Report
  • [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy2012

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Broward County convention Center( 米国)
    • Related Report
      2012 Research-status Report
  • [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy2012

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Organizer
      Seoul National University -Hokkaido University Joint Symposium in Ophthalmology
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス網膜発生における(プロ)レニン受容体の機能解析2012

    • Author(s)
      神田敦宏、野田航介、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋.
    • Organizer
      第35回 日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 網膜疾患および発生における(プロ)レニン受容体の機能解析2012

    • Author(s)
      神田敦宏、野田航介、齋藤 航、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋.
    • Organizer
      第2回わかもと先進医療研究会
    • Place of Presentation
      ロイヤルパークホテル(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] (プロ)レニン受容体の増殖糖尿病網膜症組織検体における血管新生活動性への関与2012

    • Author(s)
      神田敦宏、野田航介、齋藤 航、石田 晋.
    • Organizer
      第116回 日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Book] Roles of the retinal pigment epithelium in neuroprotection. Neuroprotection and Regeneration for Retinal Diseases.2014

    • Author(s)
      Kanda A, Ishida S.
    • Total Pages
      341
    • Publisher
      Springer.
    • Related Report
      2014 Annual Research Report
  • [Book] 糖尿病網膜症における(プロ)レニン受容体の血管新生活動性への関与.2012

    • Author(s)
      神田敦宏、野田航介、齋藤 航、石田 晋.
    • Total Pages
      2
    • Publisher
      北海道医学雑誌BAY
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi