Functional analysis of receptor-associated prorenin system in the retina

• Project/Area Number: 24791823
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: KANDA Atsuhiro 北海道大学, 医学(系)研究科(研究院), 特任講師 (80342707)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: (プロ)レニン受容体 / プロレニン / レニン・アンジオテンシン 系 / 血管新生 / 網膜疾患 / レニン・アンジオテンシン系 / （プロ）レニン受容体

Outline of Final Research Achievements

(Pro)renin receptor is known to regulate tissue RAS and RAPS, and involved in the pathogenesis of several ocular disorders. However, its physiological functions remain unclear. The goal of this study is to gain additional insights into the pathological and biological function of (pro)renin receptor using clinical samples and animal models.

Research Products

• [Journal Article] ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 b-subunit. (2015)
  • Author(s): Kanda A, Noda K, Ishida S.
  • Journal Title: J Biol Chem. Volume: 290 Issue: 15 Pages: 9690-9700
  • DOI: 10.1074/jbc.m114.626713
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of the receptor-associated prorenin system in the pathogenesis of human conjunctival lymphoma. (2014)
  • Author(s): Ishizuka ET, Kanda A, Kase S, Noda K, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 1 Pages: 74-80
  • DOI: 10.1167/iovs.14-15743
  • Peer Reviewed / Open Access
• [Journal Article] Genistein attenuates choroidal neovascularization (2014)
  • Author(s): Kinoshita S, Noda K, Tagawa Y, Inafuku S, Dong Y, Fukuhara J, Dong Z, Ando R, Kanda A, Ishida S
  • Journal Title: J Nutr Biochem Volume: 25 Issue: 11 Pages: 1177-1182
  • DOI: 10.1016/j.jnutbio.2014.06.004
  • Peer Reviewed / Open Access
• [Journal Article] A comparison of N-glycan profiles in human plasma and vitreous fluid. (2014)
  • Author(s): Inafuku S, Noda K, Amano M, Ohashi, Yoshizawa C, Saito W, Kanda A, Nishimura S, Ishida S.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. Volume: 252 Issue: 8 Pages: 1235-1243
  • DOI: 10.1007/s00417-014-2671-x
  • Peer Reviewed / Open Access
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde derived-advanced glycation end product formation. (2014)
  • Author(s): Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S
  • Journal Title: J Leukoc Biol Volume: 96 Issue: 6 Pages: 1077-1085
  • DOI: 10.1189/jlb.3a0513-288rrr
  • Peer Reviewed / Open Access
• [Journal Article] Decreased proteasomal activity causes photoreceptor degeneration in mice. (2014)
  • Author(s): Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Issue: 7 Pages: 4682-4690
  • DOI: 10.1167/iovs.13-13272
  • Peer Reviewed / Open Access
• [Journal Article] Aqueous humor levels of placental growth factor in diabetic retinopathy (2014)
  • Author(s): Ando R, Noda K, Namba S, Saito W, Kanda A, Ishida S
  • Journal Title: Acta Ophthalmol Volume: 92 Issue: 3 Pages: 245-246
  • DOI: 10.1111/aos.12251
  • Peer Reviewed / Open Access
• [Journal Article] A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase. (2014)
  • Author(s): Saito M, Saito W, Kanda A, Ohguro H, Ishida S.
  • Journal Title: BMC Ophthalmol. Volume: 14 Issue: 1 Pages: 5-5
  • DOI: 10.1186/1471-2415-14-5
  • Peer Reviewed
• [Journal Article] Expression of vascular endothelial growth factor in human ocular adnexal lymphoma. (2014)
  • Author(s): Kinoshita S, Kase S, Ando R, Dong Z, Fukuhara J, Dong Y, Takashina S, Noda K, Noda M, Kanda A, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 55 Issue: 6 Pages: 3461-3467
  • DOI: 10.1167/iovs.13-13510
  • Peer Reviewed / Open Access
• [Journal Article] 増殖糖尿病網膜症の病態形成における（プロ）レニン受容体. (2014)
  • Author(s): 神田敦宏
  • Journal Title: 日本眼科学会雑誌 Volume: 118 Pages: 916-926
  • Peer Reviewed
• [Journal Article] 糖尿病網膜症とRAS (2014)
  • Author(s): 神田敦宏、石田 晋
  • Journal Title: Angiotensin Research Volume: 11 Pages: 190-193
  • Peer Reviewed
• [Journal Article] Expression of vascular endothelial growth factor in eyes with Coats disease. (2013)
  • Author(s): Kase S, Rao NA, Yoshikawa H, Fukuhara J, Noda K, Kanda A, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54 Issue: 1 Pages: 57-62
  • DOI: 10.1167/iovs.12-10613
  • Peer Reviewed
• [Journal Article] Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor. (2013)
  • Author(s): Fukuhara J, Noda K, Murata M, Namba S, Kinoshita S, Dong Z, Ando R, Lennikov A, Kanda A, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 54 Issue: 1 Pages: 274-279
  • DOI: 10.1167/iovs.12-10512
  • Peer Reviewed
• [Journal Article] Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy. (2013)
  • Author(s): Kanda A, Noda K, Saito W, Ishida S.
  • Journal Title: Br J Ophthalmol. Volume: 97 Issue: 5 Pages: 666-668
  • DOI: 10.1136/bjophthalmol-2012-302680
  • Peer Reviewed
• [Journal Article] Expression of vascular endothelial growth factor C in human pterygium. (2013)
  • Author(s): Fukuhara J, Kase S, Ohashi T, Ando R, Dong Z, Noda K, Ohguchi T, Kanda A, Ishida S.
  • Journal Title: Histochem Cell Biol Volume: 139 Issue: 2 Pages: 381-389
  • DOI: 10.1007/s00418-012-1019-z
  • NAID: 120005228265
  • Peer Reviewed
• [Journal Article] Vitreous renin-angiotensin system is mediated by soluble (pro)renin receptor in diabetic retinopathy: new implication of receptor-associated prorenin system. (2013)
  • Author(s): Kanda A, Ishida S.
  • Journal Title: Twn J Ophthalmol. Volume: 3 Pages: 51-53
  • Peer Reviewed
• [Journal Article] Atp6ap2/(Pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. (2013)
  • Author(s): Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A & Ishida S
  • Journal Title: J Neurosci. Volume: 33 Issue: 49 Pages: 19341-19351
  • DOI: 10.1523/jneurosci.1362-13.2013
  • NAID: 120005438252
  • Peer Reviewed
• [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. (2013)
  • Author(s): Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
  • Journal Title: Mol Vis. Volume: 19 Pages: 536-543
  • NAID: 120005372289
  • Peer Reviewed
• [Journal Article] Expression of alphaB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma. (2013)
  • Author(s): Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Dong Y, Takashina S, Kanda A, Noda M, Noda K, Ishida S.
  • Journal Title: Anticancer Res. Volume: 33 Pages: 3745-3751
  • Peer Reviewed
• [Journal Article] Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy (2013)
  • Author(s): Yaguchi H, Yabe I, Takahashi H, Okumura F, Takeuchi A, Horiuchi, K, Kan T, Kanda, A, Saito W, Matsumoto M, Nakayama KI, Hatakeyama S and Sasaki H
  • Journal Title: J. Neurol. Volume: 261 Issue: 1 Pages: 224-226
  • DOI: 10.1007/s00415-013-7134-5
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye. (2012)
  • Author(s): Kanda A, Noda K, Oike Y, Ishida S.
  • Journal Title: Lab Invest. Volume: 92 Pages: 1553-1563
  • NAID: 120005228682
  • Peer Reviewed
• [Journal Article] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy. (2012)
  • Author(s): Kanda A, Noda K, Saito W, Ishida S.
  • Journal Title: Diabetologia. Volume: 55 Pages: 3104-3113
  • NAID: 40019966951
  • Peer Reviewed
• [Journal Article] Receptor-associated prorenin system in the pathogenesis of retinal diseases. (2012)
  • Author(s): Satofuka S, Kanda A, Ishida S.
  • Journal Title: Front Biosci. Volume: 4 Pages: 1449-1460
  • Peer Reviewed
• [Presentation] Identification of (pro)renin receptor/Atp6ap2-binding proteins in the retina of adult mice. (2015)
  • Author(s): Kanda A, Noda K, Ishida S.
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Florida, USA
  • Year and Date: 2015-05-04 – 2015-05-08
• [Presentation] （プロ）レニン受容体と糖代謝 (2015)
  • Author(s): 神田敦宏
  • Organizer: 第7回（プロ）レニン受容体フォーラム
  • Place of Presentation: 熊本大学（熊本県、熊本市）
  • Year and Date: 2015-03-21
• [Presentation] ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the E1 β subunit of pyruvate dehydrogenase complex. (2015)
  • Author(s): Kanda A, Noda K, Ishida S.
  • Organizer: Asia-ARVO 2015
  • Place of Presentation: Pacifico Yokohama(Kanagawa, Yokohama）
  • Year and Date: 2015-02-16 – 2015-02-19
• [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mice. (2015)
  • Author(s): Kanda A.
  • Organizer: Asia-ARVO 2015
  • Place of Presentation: Pacifico Yokohama(Kanagawa, Yokohama）
  • Year and Date: 2015-02-16 – 2015-02-19
  • Invited
• [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mouse. (2015)
  • Author(s): Kanda A.
  • Organizer: 2015 Meeting with Hokkaido University & Chang Gung Memorial Hospitals
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-01-31
• [Presentation] Atp6ap2/(pro)renin receptor is associated with cell polarity required for laminar formation during retinal development in mouse. (2014)
  • Author(s): Kanda A
  • Organizer: 9th Japan-Korea International Symposium in Ophthalmology
  • Place of Presentation: Hokkaido University（Hokkaido, Sapporo)
  • Year and Date: 2014-12-01
• [Presentation] 網膜におけるレニン・アンジオテンシン系 (2014)
  • Author(s): 神田敦宏
  • Organizer: 第1回眼科基礎研究の会
  • Place of Presentation: ホテル三浦華園（北海道、滝川市）
  • Year and Date: 2014-08-23
• [Presentation] Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. (2014)
  • Author(s): Kanda A, Yuki K, Furukawa T, Ichihara A, Ishida S.
  • Organizer: World Ophthalmology Congress 2014 Tokyo
  • Place of Presentation: Tokyo International Forum（Tokyo, Chiyoda)
  • Year and Date: 2014-04-02 – 2014-04-04
• [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy (2014)
  • Author(s): 神田敦宏
  • Organizer: 第118回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2014-04-02 – 2014-04-04
• [Presentation] Functional analysis of (pro)renin receptor in mouse retinal development (2013)
  • Author(s): Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S.
  • Organizer: The 11th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 北海道大学（北海道）
• [Presentation] Functional analysis of (pro)renin receptor in mouse retinal development (2013)
  • Author(s): Kanda A, Noda K, Yuki K, Ozawa Y, Fukuhara T, Ichihara A, Ishida S.
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Washington State Convention Center (Seattle, USA)
• [Presentation] マウス網膜発生における（プロ）レニン受容体の生理的機能解析 (2013)
  • Author(s): 神田敦宏、野田航介、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋
  • Organizer: 第117回 日本眼科学会
  • Place of Presentation: 東京国際フォーラム（東京）
• [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy (2012)
  • Author(s): Kanda A, Noda K, Saito W, Ishida S.
  • Organizer: 10th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: Hokkaido University（Sapporo, Japan）
• [Presentation] ARMS2 Association with the Mitochondrial Outer Membrane is Reduced in RPE Cells Exposed to Oxidative Stress and in AMD (2012)
  • Author(s): Boulton M, Qi X, Kanda A, Nellissery J, Mitter S, Grant M, Swaroop A.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Broward County convention Center（ 米国）
• [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy (2012)
  • Author(s): Kanda A, Noda K, Saito W, Ishida S.
  • Organizer: ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
  • Place of Presentation: Broward County convention Center（ 米国）
• [Presentation] (Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy (2012)
  • Author(s): Kanda A, Noda K, Saito W, Ishida S.
  • Organizer: Seoul National University -Hokkaido University Joint Symposium in Ophthalmology
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] マウス網膜発生における（プロ）レニン受容体の機能解析 (2012)
  • Author(s): 神田敦宏、野田航介、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋.
  • Organizer: 第35回 日本分子生物学会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] 網膜疾患および発生における（プロ）レニン受容体の機能解析 (2012)
  • Author(s): 神田敦宏、野田航介、齋藤 航、結城賢弥、小沢洋子、古川貴久、市原淳弘、石田 晋.
  • Organizer: 第2回わかもと先進医療研究会
  • Place of Presentation: ロイヤルパークホテル（東京）
• [Presentation] （プロ）レニン受容体の増殖糖尿病網膜症組織検体における血管新生活動性への関与 (2012)
  • Author(s): 神田敦宏、野田航介、齋藤 航、石田 晋.
  • Organizer: 第116回 日本眼科学会
  • Place of Presentation: 東京国際ﾌｫｰﾗﾑ（東京）
• [Book] Roles of the retinal pigment epithelium in neuroprotection. Neuroprotection and Regeneration for Retinal Diseases. (2014)
  • Author(s): Kanda A, Ishida S.
  • Total Pages: 341
  • Publisher: Springer.
• [Book] 糖尿病網膜症における（プロ）レニン受容体の血管新生活動性への関与. (2012)
  • Author(s): 神田敦宏、野田航介、齋藤 航、石田 晋.
  • Total Pages: 2
  • Publisher: 北海道医学雑誌BAY