VEGF-C, a lymphangiogenic factor, and its receptor system in pterygium
| Project/Area Number |
24791824
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | VEGF-C / 翼状片 / インターロイキン |
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| Outline of Final Research Achievements |
In this study, there were many D2-40, a marker for lymphatic vessels, positive cells beneath the epithelium in human pterygium. D2-40-positive cells were consistent with lymphatic endothelial cells. A few lymphatic vessels were noted in the normal conjunctiva. Quantitative analyses revealed that lymphatic densities were significantly greater in pterygium than normal conjunctiva. Moreover, VEGFR-3 immunoreactivity was detected in the lymphatic vessels as well. We further analyzed the mechanisms underlying the induction of VEGF-C. In this study, VEGF-C secretion was induced 48 hours after serum starvation in cultured conjunctival epithelial cells. VEGF-C secretion was further stimulated 48 hours after treatment with interleukin 1beta, an inflammatory cytokine.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Safety evaluation of novel drug delivery device, the conjunctival ring2014
Author(s)
Kinoshita S, Noda K, Takashina S, Dong Y, Atsumi I, Obata H, Matsunaga T, Ohguchi T, Kanda A, Ishida S
Organizer
ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
Place of Presentation
Orange County Convention Center（Orlando,USA）
Year and Date
2014-05-04 – 2014-05-08
Related Report
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