| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, there were many D2-40, a marker for lymphatic vessels, positive cells beneath the epithelium in human pterygium. D2-40-positive cells were consistent with lymphatic endothelial cells. A few lymphatic vessels were noted in the normal conjunctiva. Quantitative analyses revealed that lymphatic densities were significantly greater in pterygium than normal conjunctiva. Moreover, VEGFR-3 immunoreactivity was detected in the lymphatic vessels as well. We further analyzed the mechanisms underlying the induction of VEGF-C. In this study, VEGF-C secretion was induced 48 hours after serum starvation in cultured conjunctival epithelial cells. VEGF-C secretion was further stimulated 48 hours after treatment with interleukin 1beta, an inflammatory cytokine.
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