Evaluation of vascular adhesion protein-1 inhibition on animal model of uveitis
| Project/Area Number |
24791825
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAKEMOTO YUKO 北海道大学, 医学(系)研究科(研究院), 客員研究員 (20443939)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | VAP-1 / 実験的自己免疫性ぶどう膜網膜炎 / ぶどう膜炎 / EAU |
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| Outline of Final Research Achievements |
1. VAP-1 expression: It was determined that VAP-1 was expressed in retina and choroid in naive mice by using western blotting and PCR. 2. VAP-1 inhibitor into EAU: EAU was induced in mice by immunization with IRBP peptide, and VAP-1 inhibitor was injected systemically. Mice treated with VAP-1 inhibitor had a tendency to be mild. However, it was not significant. 3. Cytokines: Soluble VAP-1 concentrations were elevated when vascular endothelial cells were stimulated with TNF-alpha and IL-1beta, however, VAP-1 mRNA levels were not elevated.
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Report
(4 results)
Research Products
(19 results)
