• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of vascular adhesion protein-1 inhibition on animal model of uveitis

Research Project

Project/Area Number 24791825
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

TAKEMOTO YUKO  北海道大学, 医学(系)研究科(研究院), 客員研究員 (20443939)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsVAP-1 / 実験的自己免疫性ぶどう膜網膜炎 / ぶどう膜炎 / EAU
Outline of Final Research Achievements

1. VAP-1 expression: It was determined that VAP-1 was expressed in retina and choroid in naive mice by using western blotting and PCR. 2. VAP-1 inhibitor into EAU: EAU was induced in mice by immunization with IRBP peptide, and VAP-1 inhibitor was injected systemically. Mice treated with VAP-1 inhibitor had a tendency to be mild. However, it was not significant. 3. Cytokines: Soluble VAP-1 concentrations were elevated when vascular endothelial cells were stimulated with TNF-alpha and IL-1beta, however, VAP-1 mRNA levels were not elevated.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis (TINU) syndrome.2013

    • Author(s)
      Takemoto Y, Namba K, Mizuuchi K, Ohno S, Ishida S.
    • Journal Title

      Eur J Ophthalmol

      Volume: 23 Issue: 2 Pages: 255-257

    • DOI

      10.5301/ejo.5000240

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between elevation of serum antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab.2012

    • Author(s)
      Iwata D, Namba K, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250 Issue: 7 Pages: 1081-1087

    • DOI

      10.1007/s00417-011-1908-1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between choroidal blood flow velocity and choroidal thickenss during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease2015

    • Author(s)
      Hirooka K, Saito W, Namba K, Takemoto Y, Mizuuchi K, Uno T, Tagawa Y, Saito M, Hashimoto Y, Ishida S
    • Organizer
      Asia-ARVO(Association for Research in Vision and Ophthalmology)2015
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] The appearance of antibodies to infliximab in the course of infliximab administration in Behcet’s disease2014

    • Author(s)
      Namba K, Mizuuchi K, Takemoto Y, Tagawa Y, Uno T, Fukuhara T, Ohno S, Kitaichi N, Ishida S
    • Organizer
      16th International Conference on Behcet’s disease
    • Place of Presentation
      Cite Internationale Universitaire de Paris(Paris,France)
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Correlation between ocular inflammatory attacks and serum trough level of infliximab or serum concentration of cytokines in the clinical course of behcet’s disease patients with infliximab treatment2014

    • Author(s)
      Mizuuchi K, Namba K, Takemoto Y, Ohno S, Ishida S
    • Organizer
      World Ophtalmology Congress 2014 Tokyo
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical features of secondary glaucoma with gonio nodules2014

    • Author(s)
      Takemoto Y, Namba K, Chin S, Sugiyama K, Ishida S
    • Organizer
      World Ophtalmology Congress 2014 Tokyo
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2014-04-02 – 2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] ぶどう膜炎に続発した血管増殖性網膜腫瘍の2症例2013

    • Author(s)
      水内一臣、南場研一、齋藤 航、堀江幸弘、田川義晃、宇野友絵、竹本裕子、福原崇子、北市伸義、石田 晋
    • Organizer
      第67回 日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ぶどう膜炎における網羅的糖差解析2013

    • Author(s)
      南場研一、北市伸義、安藤 亮、竹本裕子、水内一臣、堀江幸弘、大野重昭、天野麻穂、西村紳一郎、石田 晋
    • Organizer
      第117回 日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] Correlation between development of antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behcet's disease with infliximab2012

    • Author(s)
      Namba K, Iwata D, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      横浜コンベンションセンター( 横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of Infliximab Therapy in Behcet's disease2012

    • Author(s)
      Takemoto Y, Namba K, Kitaichi N, Mizuuchi K, Ohno S, Ishida S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      横浜コンベンションセンター( 横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Vogt-小柳原田病の前眼部炎症再発時における脈絡膜循環障害2012

    • Author(s)
      竹本裕子、南場研一、水内一臣、橋本勇希、宇野友絵、北市伸義、大野重昭、石田 晋.
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      国立京都国際会館( 京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] 多発脳神経炎の治療中に急性網膜壊死を発症した1例2012

    • Author(s)
      水内一臣、南場研一、齋藤 航、堀内一宏、加納崇裕、竹本裕子、北市伸義、大野重昭、石田 晋.
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      国立京都国際会館( 京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] 隅角結節を伴う続発緑内障の臨床像2012

    • Author(s)
      竹本裕子、新田卓也、南場研一、水内一臣、宇野友絵、大口剛司、新明康弘、陳 進輝、石田 晋.
    • Organizer
      第23回 緑内障学会
    • Place of Presentation
      ANAクラウンプラザホテル( 金沢市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 尋常性感癬に伴う難治性ぶどう膜炎に対しインフリキシマブ治療が奏功した1例2012

    • Author(s)
      櫻井友梨、南場研一、水内一臣、竹本裕子、宇野友絵、及村俊史、大野重昭、石田 晋.
    • Organizer
      第159回 北海道眼科集談会
    • Place of Presentation
      旭川ターミナルホテル( 旭川市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 網膜色素上皮裂孔および漿液性網膜剥離を伴ったぶどう膜炎2012

    • Author(s)
      田川義晃、南場研一、水内一臣、竹本裕子、北市伸義、大野重昭、石田 晋.
    • Organizer
      第46回 眼炎症学会
    • Place of Presentation
      パシフィコ横浜( 横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Relentless placoid chorioretinitisの1例2012

    • Author(s)
      竹本裕子、南場研一、齋藤 航、水内一臣、北市伸義、大野重昭、石田 晋.
    • Organizer
      第46回 眼炎症学会
    • Place of Presentation
      パシフィコ横浜( 横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 肺粟粒結核に伴う結核性眼内炎の1例2012

    • Author(s)
      長谷敬太郎、南場研一、竹本裕子、齋藤 航、中村佳代子、今野 哲、網島 優、大野重昭、石田 晋.
    • Organizer
      第46回 眼炎症学会
    • Place of Presentation
      パシフィコ横浜( 横浜市)
    • Related Report
      2012 Research-status Report
  • [Book] Behcet病. 特集ステロイド薬抵抗性ぶどう膜炎:治療の最前線.2012

    • Author(s)
      竹本裕子、南場研一.
    • Publisher
      あたらしい眼科
    • Related Report
      2012 Research-status Report
  • [Book] Behcet病. 6. 内因性ぶどう膜炎.2012

    • Author(s)
      竹本裕子、南場研一.
    • Publisher
      眼科診療クオリファイ
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi