New regulating factor of retinal circulation and establishment of treatment of diabetic retinopathy
| Project/Area Number |
24791828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
OMAE Tsuneaki 旭川医科大学, 医学部, その他 (30451470)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 網膜循環 / 糖尿病網膜症 |
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| Research Abstract |
We showed that adiponectin, an important adipocytokine secreted by adipocytes, elicits mainly endothelium-dependent dilation of the retinal arterioles. Furthermore, there appears to e a positive relationship between plasma concentration of adiponectin and retinal blood flow in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus. Because, our previous clinical study found that RBF is impaired in early-stage diabetic retinopathy in patients with type 2 diabetes mellitus, it is likely that a decreased serum adiponectin level may impair the RBF, resulting in development of retinopathy, in patients with type 2 diabetes mellitus. therapeutic interventions that enhance the actions of adiponectin may lead to a novel potential treatment.
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Report
(3 results)
Research Products
(5 results)
