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Role of antioxidant enzyme in inherited retinal degeneration

Research Project

Project/Area Number 24791837
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionThe University of Tokyo

Principal Investigator

OBATA Ryo  東京大学, 医学部附属病院, 助教 (80625434)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords網膜変性 / 抗酸化酵素 / グルタチオンペルオキシダーゼ / GPx4
Outline of Final Research Achievements

A lot of materials were reported as candidates for antioxidant therapy of hereditary retinal dystrophy. Since glutathione peroxidase 4 (GPx4), one of the antioxidant enzymes, was found essential for maturation of photoreceptor cells recently, we studied the role of GPx4 on hereditary. As a result GPx4 was associated with progression of retinal atrophy in a murine model of inherited retinal degeneration. Therefore, GPx4 was suggested to be a novel candidate of the target for antioxidant therapy against inherited retinal degeneration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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