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Therapeutic potential of semaphorin 3E for the treatment of choroidal neovascularization

Research Project

Project/Area Number 24791847
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

OISHI Akio  京都大学, 医学(系)研究科(研究院), 助教 (50572955)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脈絡膜新生血管 / semaphorin3E / plexinD1 / PlexinD1 / Semaphorin3E / 眼生化学・分子生物学
Research Abstract

We performed the study to investigate the effects of Semaphorin3E (Sema3E)/PlexinD1 signal in the development of choroidal neovascularization (CNV) and explore the therapeutic potential of the pathway. We used a laser-induced CNV model in mouse. The presence of PlexinD1 was confirmed immunohistochemically in the endothelial cells of CNV. Intravitreal injection of recombinant Sema3E decreased the CNV size in a dose-dependent manner. This inhibitory effect of Sema3E in the formation of CNV was canceled in the PlexinD1 knockout mice. These results indicate that Sema3E-PlexinD1 signal is involved in the development of CNV and stimulation of the pathway has the therapeutic potential for CNV.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2014 2013 2012 Other

All Journal Article (19 results) Presentation (4 results)

  • [Journal Article] Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography2014

    • Author(s)
      Ueda-Arakawa N, Ooto S, Ellabban AA, Takahashi A, Oishi A, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] LAPTOP Study : A 24-Month Trial of Verteporfin Versus Ranibizumab for Polypoidal Choroidal Vasculopathy2014

    • Author(s)
      Oishi A, Miyamoto N, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Bessho N, Uenishi M, Kurimoto Y, Negi A
    • Journal Title

      Ophthalmology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multimodal evaluation of macular function in age-related macular degeneration2014

    • Author(s)
      Ogino K, Tsujikawa A, Yamashiro K, Ooto S, Oishi A, Nakata I, Miyake M, Takahashi A, Ellabban AA, Yoshimura N
    • Journal Title

      Jpn J Ophthalmol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vascular Endothelial Growth Factor Gene and the Response to Anti-Vascular Endothelial Growth Factor Treatment for Choroidal Neovascularization in High Myopia2014

    • Author(s)
      Miyake M, Yamashiro K, Akagi-Kurashige Y, Kumagai K, Nakata I, Nakanishi H, Oishi A, Tsujikawa A, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Ophthalmology

      Volume: 121(1) Pages: 225-33

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reduction of Retinal Sensitivity in Eyes With Reticular Pseudodrusen2013

    • Author(s)
      Ooto S, Ellabban AA, Ueda-Arakawa N, Oishi A, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 156(6) Pages: 1184-1191

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nagahama Study Group. Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy2013

    • Author(s)
      Nakata I, Yamashiro K, Kawaguchi T, Gotoh N, Nakanishi H, Akagi-Kurashige Y, Miyake M, Tsujikawa A, Oishi A, Saito M, Iida T, Yamada R, Matsuda F, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Comparison of the effect of ranibizumab and verteporfin for polypoidal choroidal vasculopathy : 12-month LAPTOP study results2013

    • Author(s)
      Oishi A, Kojima H, Mandai M, Honda S, Matsuoka T, Oh H, Kita M, Nagai T, Fujihara M, Bessho N, Uenishi M, Kurimoto Y, Negi A
    • Journal Title

      Am J Ophthalmol

      Volume: 156(4) Pages: 644-51

    • Related Report
      2013 Final Research Report
  • [Journal Article] Focal choroidal excavation in eyes with central serous chorioretinopathy2013

    • Author(s)
      Ellabban AA, Tsujikawa A, Ooto S, Yamashiro K, Oishi A, Nakata I, Miyake M, Akagi-Kurashige Y, Ueda-Arakawa N, Arichika S, Yoshitake S, Takahashi A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 156(4) Pages: 673-83

    • Related Report
      2013 Final Research Report
  • [Journal Article] Intravitreal injection of ranibizumab for recovery of macular function in eyes with subfoveal polypoidal choroidal vasculopathy2013

    • Author(s)
      Ogino K, Tsujikawa A, Yamashiro K, Ooto S, Oishi A, Nakata I, Miyake M, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54(5) Pages: 3771-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sensitivity and specificity of detecting reticular pseudodrusen in multimodal imaging in Japanese patients2013

    • Author(s)
      Ueda-Arakawa N, Ooto S, Tsujikawa A, Yamashiro K, Oishi A, Yoshimura N
    • Journal Title

      Retina

      Volume: 33(3) Pages: 490-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration2013

    • Author(s)
      Oishi A, Shimozono M, Mandai M, Hata M, Nishida A, Kurimoto Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 251(2) Pages: 435-40

    • NAID

      120005474470

    • Related Report
      2013 Final Research Report
  • [Journal Article] Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization2013

    • Author(s)
      Oishi A, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Nakata I, Miyake M, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 251(1) Pages: 1-7

    • NAID

      120005241384

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prevalence and genomic association of reticular pseudodrusen in age-related macular degeneration2012

    • Author(s)
      Ueda-Arakawa N, Ooto S, Nakata I, Yamashiro K, Tsujikawa A, Oishi A, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 155(2) Pages: 260-269

    • Related Report
      2013 Final Research Report
  • [Journal Article] Macular choroidal thickness measured by swept source optical coherence tomography in eyes with inferior posterior staphyloma2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Matsumoto A, Yamashiro K, Oishi A, Ooto S, Nakata I, Akagi-Kurashige Y, Miyake M, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(12) Pages: 7735-45

    • Related Report
      2013 Final Research Report
  • [Journal Article] Choroidal thickness after intravitreal ranibizumab injections for choroidal neovascularization2012

    • Author(s)
      Ellabban AA, Tsujikawa A, Ogino K, Ooto S, Yamashiro K, Oishi A, Yoshimura N
    • Journal Title

      Clin Ophthalmol

      Volume: 6 Pages: 837-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy2012

    • Author(s)
      Jirarattanasopa P, Ooto S, Nakata I, Tsujikawa A, Yamashiro K, Oishi A, Yoshimura N.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(7) Pages: 3663-72

    • Related Report
      2013 Final Research Report
  • [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration2012

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250(8) Pages: 1129-36

    • Related Report
      2013 Final Research Report
  • [Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanshi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 794-798

    • Related Report
      2013 Final Research Report
  • [Journal Article] Therapeutic potential of semaphorin 3E for the treatment of choroidal neovascularization

    • Author(s)
      Kenji Suda, Congrong Guo, Akio Oishi, Shinya Ikeda, Akiyoshi Uemura, Nagahisa Yoshimura
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] Semaphorin3E/PlexinD1 シグナル経路による脈絡膜新生血管形成の抑制効果2013

    • Author(s)
      須田謙史, 大石明生, ら
    • Organizer
      厚生労働省難治性疾患克服研究事業網膜脈絡膜・視神経萎縮症調査研究斑
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Semaphorin3E/PlexinD1 シグナル経路による脈絡膜新生血管形成の抑制効果2013

    • Author(s)
      須田謙史, 郭从容, 大石明生, ら
    • Organizer
      第117回二本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Semaphorin3E/PlexinD1シグナル経路による脈絡膜新生血管形成の抑制効果.2013

    • Author(s)
      須田謙史、郭从容、大石明生、池田真也、吉村長久
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Semaphorin3E/PlexinD1シグナル経路による脈絡膜新生血管形成の抑制効果2013

    • Author(s)
      須田謙史、大石明生 他
    • Organizer
      厚生労働省難治性疾患克服研究事業網膜脈絡膜・視神経萎縮症調査研究斑
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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