| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
I investigated the pathogenesis of diabetic macular edema (DME) using optical coherence tomography (OCT). I established a novel methods for the segmentation of inner and outer retinal layers, following the measurements of these layers. Second, I performed the comparative study about the mechanisms of distrubance in foveal photoreceptor, and found the association between hyperreflective foci, external limiting membrane, the junction of inner and outer segments of photoreceptor cells. In addition, I demonstrated the pathogenesis of the development of serous retinal detachment and foveal cystoid spaces, depending on either retinal vascular hyperpermeability in the perifovea or the retinal vascular changes in the fovea or parafovea.
Finally, we applied self-organizing map for the analyses of multi-dimensional data, and showed novel associations and dissociations of OCT findings or parameters, and proposed a novel classification of morphological patterns in dmabetic macular edema
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