Investigation of the roles of Mrp4 in retinal angiogenesis
| Project/Area Number |
24791854
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
KUSUHARA SENTARO 神戸大学, 医学(系)研究科(研究院), 助教 (40437463)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Ｍｒｐ４ / ＡＢＣトランスポーター / 網膜 / 血管新生 / 酸素誘発網膜症モデル / MRP4 / 周皮細胞 / cAMP |
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| Outline of Final Research Achievements |
This study showed Mrp4, an efflux transporter, is intricately associated with physiological retinal angiogenesis by regulating intracellular cAMP level. Additionally, as both the formation of avascular area and extraretinal neovascularization were exacerbated in Mrp4 knockout mice in an oxygen-induced retinopathy model, Mrp4 seems to have a suppressive role in pathological retinal angiogenesis. These results suggest that Mrp4 is a promising therapeutic target for neovascular retinal diseases.
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Report
(4 results)
Research Products
(5 results)
