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Investigation of the roles of Mrp4 in retinal angiogenesis

Research Project

Project/Area Number 24791854
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKobe University

Principal Investigator

KUSUHARA SENTARO  神戸大学, 医学(系)研究科(研究院), 助教 (40437463)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMrp4 / ABCトランスポーター / 網膜 / 血管新生 / 酸素誘発網膜症モデル / MRP4 / 周皮細胞 / cAMP
Outline of Final Research Achievements

This study showed Mrp4, an efflux transporter, is intricately associated with physiological retinal angiogenesis by regulating intracellular cAMP level. Additionally, as both the formation of avascular area and extraretinal neovascularization were exacerbated in Mrp4 knockout mice in an oxygen-induced retinopathy model, Mrp4 seems to have a suppressive role in pathological retinal angiogenesis. These results suggest that Mrp4 is a promising therapeutic target for neovascular retinal diseases.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Forskolin modifies retinal vascular development in Mrp4-knockout mice2012

    • Author(s)
      Matsumiya W, Kusuhara S, Hayashibe K, Maruyama K, Kusuhara H, Tagami M, Schuetz JD, Negi A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 13 Pages: 8029-8035

    • DOI

      10.1167/iovs.12-10781

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The role of Mrp4 in pathological angiogenesis of the mouse retina2015

    • Author(s)
      Sentaro Kusuhara, Wataru Matsumiya, Makoto Nakamura
    • Organizer
      2015 ARVO Annual Meeting
    • Place of Presentation
      Denver, Colorado
    • Year and Date
      2015-05-03 – 2015-05-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 病的網膜血管新生におけるMrp4の役割2015

    • Author(s)
      楠原仙太郎、松宮亘、根木昭
    • Organizer
      第118回 日本眼科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] フォルスコリンはMrp4ノックアウトマウスにおける網膜血管形成を修飾する2013

    • Author(s)
      松宮 亘、楠原仙太郎、根木 昭
    • Organizer
      第17回眼科分子生物学研究会
    • Place of Presentation
      箱根
    • Related Report
      2012 Research-status Report
  • [Presentation] フォルスコリンはMrp4KO マウスにおける網膜血管形成を修飾する

    • Author(s)
      松宮亘、楠原仙太郎、林部恵子、丸山和一、根木昭
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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