| Project/Area Number |
24791858
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Ehime University |
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Principal Investigator |
SUZUKI Takashi 愛媛大学, 医学部附属病院, 講師 (70398048)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 黄色ブドウ球菌 / タイコ酸 / MRSA / ワクチン / 遺伝子 / 病原因子 / psm-mec / psm-α / Staphylococcus aureus / keratitis |
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| Research Abstract |
ST764 were the most frequently identified sequence types in MRSA strains from ocular site. ST764 has a mutation in psm-mec which regulates virulence factors, and increase virulence.
Wall teichoic acids (WTAs) which are major polyanionic polymer components the cell wall of Staphylococcus aureus, plays a critical role in keratitis, and WTA appears to be a viable target for treating S. aureus infection. We developed screening methods for WTA inhibitors, and found some candidates.
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