Development of vaccine eye drop against Staphylococcus aureus
Project/Area Number |
24791858
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
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Research Institution | Ehime University |
Principal Investigator |
SUZUKI Takashi 愛媛大学, 医学部附属病院, 講師 (70398048)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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Keywords | 黄色ブドウ球菌 / タイコ酸 / MRSA / ワクチン / 遺伝子 / 病原因子 / psm-mec / psm-α / Staphylococcus aureus / keratitis |
Research Abstract |
ST764 were the most frequently identified sequence types in MRSA strains from ocular site. ST764 has a mutation in psm-mec which regulates virulence factors, and increase virulence. Wall teichoic acids (WTAs) which are major polyanionic polymer components the cell wall of Staphylococcus aureus, plays a critical role in keratitis, and WTA appears to be a viable target for treating S. aureus infection. We developed screening methods for WTA inhibitors, and found some candidates.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Pseudomonas aeruginosa MucD protease mediate keratitis by inhibition of neutrophil recruitment and bacterial survival.2014
Author(s)
Mochizuki, Y., Suzuki, T., Oka, N., Zhang, Y., Hayashi, Y., Hayashi, N., Gotoh, N., and Ohashi, Y.
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Journal Title
Invest. Ophthalmol. Vis. Sci.
Volume: 55
Issue: 1
Pages: 240-246
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of a Peptide Antagonist against fsr Quorum Sensing of Enterococcus faecalis2013
Author(s)
Nakayama J, Y okohata R, Sato M, Suzuki T, Matsufuji T , Nishiguchi K, Kawai T , Y amanaka Y , Nagata K, Tanokura M, Sonomoto K
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Journal Title
ACS Chem Biol
Volume: 8
Pages: 804-11
Related Report
Peer Reviewed
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