Therapeutic potential of IL-10 producing regulatory T cells for refractory ocular inflammatory diseases
| Project/Area Number |
24791859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
YOSHIMURA Takeru 九州大学, 医学(系)研究科(研究院), 研究員 (40625802)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 眼科学 / 免疫学 / IL-27の抗炎症作用 / IL-35の抗炎症作用 / IL-10 / IL-27 / IL-35 / Th17 / ぶどう膜炎 / 眼炎症 |
|---|
| Outline of Final Research Achievements |
(1)Inflamed retina contains CD4-positive IL-10 producing cells. While IL-27 regulates Th17 infiltration, IL-35 suggested to produce IFN-γ from CD4-positive cells, which leads to Th1-induced anti-inflammatory mechanism. (2) EBI3, a subunit of IL-27/IL-35, induces Th1 response and CD4-positive IL-10 producing cells upon initial inflammation, which in turn inhibits Th1/Th17 response on late inflammatory phase presumably by increasing CD4-positive IL-10 producing cells.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] EBI3 is pivotal for the initiation of experimental autoimmune uveitis.2014
Author(s)
Takeda A, Hasegawa E, Fukuhara T, Hirakawa S, Yamada H, Yang Y, Yoshimura T, Hisatomi T, Oshima Y, Yoshida H, Sonoda KH, Ishibashi T
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Journal Title
Exp Eye Res
Volume: 125
Pages: 107-113
DOI
Related Report
Peer Reviewed
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