Therapeutic potential of IL-10 producing regulatory T cells for refractory ocular inflammatory diseases

Research Project

Project/Area Number	24791859
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Kyushu University
Principal Investigator	YOSHIMURA Takeru 九州大学, 医学(系)研究科(研究院), 研究員 (40625802)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	眼科学 / 免疫学 / IL-27の抗炎症作用 / IL-35の抗炎症作用 / IL-10 / IL-27 / IL-35 / Th17 / ぶどう膜炎 / 眼炎症
Outline of Final Research Achievements	(1)Inflamed retina contains CD4-positive IL-10 producing cells. While IL-27 regulates Th17 infiltration, IL-35 suggested to produce IFN-γ from CD4-positive cells, which leads to Th1-induced anti-inflammatory mechanism. (2) EBI3, a subunit of IL-27/IL-35, induces Th1 response and CD4-positive IL-10 producing cells upon initial inflammation, which in turn inhibits Th1/Th17 response on late inflammatory phase presumably by increasing CD4-positive IL-10 producing cells.

Report

(4 results)