Ocular innate immune response in TAX1BP1 deficient mice

• Project/Area Number: 24791861
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Oita University
• Principal Investigator: NAKANO Satoko 大分大学, 医学部, 医員 (20593809)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: TAX1BP1 / A20 / NF-κB / エンドトキシン誘発ぶどう膜炎 / キーワード1

Research Abstract

A20 (TNFAIP3) and Tax1-binding protein 1 (TAX1BP1) are known as the negative regulator of the nuclear factor (NF-kB) pathway. The polymorphism of the A20 gene is genetically linked to numerous autoimmune diseases. There were no reports of the expression A20 and TAX1BP1 in the ocular inflammation. In this study, we firstly reported the A20 expresses during endotoxin-induced uveitis and TAX1BP1-knock out mice have severe ocular inflammation than wild mice. A20 and TAX1BP1 might be controlled to uveitis like other inflammatory diseases.

Research Products

• [Journal Article] Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice. (2013)
  • Author(s): Nakano S, Ikebe E, Tsukamoto Y, Wang Y, Matsumoto T, Mitsui T, Yahiro T, Inoue K, Kawazato H, Yasuda A, Ito K, Yokoyama S, Takahashi N, Hori M, Shimada T, Moriyama M, Kubota T, Ono K, Fujibuchi W, Jeang KT, Iha H, Nishizono A.
  • Journal Title: PLoS One Volume: 8(9) Issue: 9 Pages: e73205-e73205
  • DOI: 10.1371/journal.pone.0073205
  • Peer Reviewed
• [Presentation] Expression of A20/TNF AIP3 during endotoxin-induced uveitis in C3H/HeN mice (2014)
  • Author(s): Satoko Nakano, Kenichi Kimoto, Katsuhiko Y okoyama, Kunihiro Kiyosaki, T oshiaki Kubota
  • Organizer: World Ophthalmology Congress 2014
• [Presentation] Expression of A20/TNFAIP3 during endotoxin-induced uveitis in C3H/HeN mice (2014)
  • Author(s): S Nakano, K Kimoto, K Yokoyama, K Kiyosaki, T Kubota
  • Organizer: World Ophthalmology Congress 2014
  • Place of Presentation: Tokyo
• [Presentation] TAX1BP1-deficiency evokes spatiotemporal development of systemic inflammatory symptoms and functional failures of cardiovascular system in mice (2012)
  • Author(s): Satoko Nakano
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸