Ocular innate immune response in TAX1BP1 deficient mice
| Project/Area Number |
24791861
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | TAX1BP1 / A20 / NF-κB / エンドトキシン誘発ぶどう膜炎 / キーワード1 |
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| Research Abstract |
A20 (TNFAIP3) and Tax1-binding protein 1 (TAX1BP1) are known as the negative regulator of the nuclear factor (NF-kB) pathway. The polymorphism of the A20 gene is genetically linked to numerous autoimmune diseases. There were no reports of the expression A20 and TAX1BP1 in the ocular inflammation. In this study, we firstly reported the A20 expresses during endotoxin-induced uveitis and TAX1BP1-knock out mice have severe ocular inflammation than wild mice. A20 and TAX1BP1 might be controlled to uveitis like other inflammatory diseases.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.2013
Author(s)
Nakano S, Ikebe E, Tsukamoto Y, Wang Y, Matsumoto T, Mitsui T, Yahiro T, Inoue K, Kawazato H, Yasuda A, Ito K, Yokoyama S, Takahashi N, Hori M, Shimada T, Moriyama M, Kubota T, Ono K, Fujibuchi W, Jeang KT, Iha H, Nishizono A.
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Journal Title
PLoS One
Volume: 8(9)
Issue: 9
Pages: e73205-e73205
DOI
Related Report
Peer Reviewed
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